Phenotypes associated with this allele

• Allele Symbol: Kif27^{Gt(OST441915)Lex}
• Allele Name: gene trap OST441915, Lexicon Genetics
• Allele ID: MGI:4318693
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kif27^Gt(OST441915)Lex/Kif27^Gt(OST441915)Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:5429550

Genotype
MGI:5429550

hm1

• Allelic Composition: Kif27^{Gt(OST441915)Lex}/Kif27^{Gt(OST441915)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

intraventricular hemorrhage ( J:185566 )

• intraventricular hemorrhage in lateral and third ventricles

cellular

cellular phenotype ( J:185566 )

N • notably, ciliary defects were not detected

craniofacial

abnormal internal nares morphology ( J:185566 )

• nasal passages filled with combinations of proteinaceous fluid or severe suppurative exudates

growth/size/body

growth/size/body region phenotype ( J:185566 )

N • notably, situs inversus was not detected

abnormal internal nares morphology ( J:185566 )

• nasal passages filled with combinations of proteinaceous fluid or severe suppurative exudates

decreased body size ( J:185566 )

hearing/vestibular/ear

increased susceptibility to otitis media ( J:185566 )

• bilateral suppurative otitis media is seen

immune system

increased susceptibility to otitis media ( J:185566 )

• bilateral suppurative otitis media is seen

maxillary sinus inflammation ( J:185566 )

• maxillary sinuses filled with combinations of proteinaceous fluid or severe suppurative exudates

mortality/aging

premature death ( J:185566 )

• mice are sickly, with all dying or euthanized by 8 weeks of age

nervous system

intraventricular hemorrhage ( J:185566 )

• intraventricular hemorrhage in lateral and third ventricles

abnormal brain ventricular system morphology ( J:185566 )

• hemorrhage sometimes accompanied by fibrosis and neovascularization of choroid and meninges

hydrocephaly ( J:185566 )

• marked to severe hydrocephalus

respiratory system

abnormal internal nares morphology ( J:185566 )

• nasal passages filled with combinations of proteinaceous fluid or severe suppurative exudates

maxillary sinus inflammation ( J:185566 )

• maxillary sinuses filled with combinations of proteinaceous fluid or severe suppurative exudates

impaired mucociliary clearance ( J:185566 )

• nasal passages and maxillary sinuses filled with combinations of proteinaceous fluid or severe suppurative exudates

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hydrocephalus		DOID:10908	OMIM:123155 OMIM:236600 OMIM:236635 OMIM:307000 OMIM:615219	J:185566