Phenotypes associated with this allele

• Allele Symbol: Mkln1^{Gt(OST448976)Lex}
• Allele Name: gene trap OST448976, Lexicon Genetics
• Allele ID: MGI:4321123
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mkln1^Gt(OST448976)Lex/Mkln1^Gt(OST448976)Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:5141507

Genotype
MGI:5141507

hm1

• Allelic Composition: Mkln1^{Gt(OST448976)Lex}/Mkln1^{Gt(OST448976)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:174709 )

N • brain slices exhibit normal gross morphology

abnormal GABAergic neuron morphology ( J:174709 )

• neurons exhibit extrasynaptic surface membrane accumulation of GABA receptors due to impaired GABA receptor internalization, intracellular trafficking, and degradation compared with wild-type cells

abnormal nervous system physiology ( J:174709 )

• sharp wave ripples in hippocampal slices exhibit enhanced power component in the ripple frequency range compared to in wild-type slices

• the distribution of cumulated ripple power in hippocampal slices is shifted to higher values compared to in wild-type slices

pigmentation

diluted coat color ( J:174709 )

• coat colors pale as mice age

integument

diluted coat color ( J:174709 )

• coat colors pale as mice age