Phenotypes associated with this allele

• Allele Symbol: M1ap^{Gt(RRO290)Byg}
• Allele Name: gene trap RRO290, BayGenomics
• Allele ID: MGI:4329148
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	M1ap^Gt(RRO290)Byg/M1ap^Gt(RRO290)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:5800476

Genotype
MGI:5800476

hm1

• Allelic Composition: M1ap^{Gt(RRO290)Byg}/M1ap^{Gt(RRO290)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal male germ cell morphology ( J:194507 )

♂ • beginning at P14, progressive

♂ • highly disorganized germinal epithelium

oligozoospermia ( J:194507 )

♂ • severe

globozoospermia ( J:194507 )

♂

abnormal male meiosis ( J:194507 )

♂ • abnormal metaphase I with misaligned chromosomes at the metaphase plate

♂ • non-homologous pairing of autosomes

♂ • failure to form crossover foci

abnormal X-Y chromosome synapsis during male meiosis ( J:194507 )

♂

arrest of male meiosis ( J:194507 )

♂ • in meiosis I

abnormal male germ cell apoptosis ( J:194507 )

♂

abnormal seminiferous tubule morphology ( J:194507 )

♂ • with vacuolization

small seminiferous tubules ( J:194507 )

♂

seminiferous tubule degeneration ( J:194507 )

♂ • varied, of all cells except spermatogonia and Sertoli cells

small testis ( J:194507 )

♂ • varied

decreased testis weight ( J:194507 )

♂ • varied

male infertility ( J:194507 )

♂

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:194507 )

♂ • impaired in male germ cells

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:194507 )

♂ • with vacuolization

small seminiferous tubules ( J:194507 )

♂

seminiferous tubule degeneration ( J:194507 )

♂ • varied, of all cells except spermatogonia and Sertoli cells

small testis ( J:194507 )

♂ • varied

decreased testis weight ( J:194507 )

♂ • varied

cellular

abnormal male germ cell morphology ( J:194507 )

♂ • beginning at P14, progressive

♂ • highly disorganized germinal epithelium

oligozoospermia ( J:194507 )

♂ • severe

globozoospermia ( J:194507 )

♂

abnormal male meiosis ( J:194507 )

♂ • abnormal metaphase I with misaligned chromosomes at the metaphase plate

♂ • non-homologous pairing of autosomes

♂ • failure to form crossover foci

abnormal X-Y chromosome synapsis during male meiosis ( J:194507 )

♂

arrest of male meiosis ( J:194507 )

♂ • in meiosis I

abnormal male germ cell apoptosis ( J:194507 )

♂

abnormal double-strand DNA break repair ( J:194507 )

♂ • impaired in male germ cells