Analysis Tools|
Allele Symbol Allele Name Allele ID |
Kdm5bGt(RRO123)Byg gene trap RRO123, BayGenomics MGI:4329395 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• Background Sensitivity: normal numbers of homozygotes are produced in heterozygous x heterozygous matings; however, numbers are reduced on the FVB/N background
• Background Sensitivity: the adult mortality rate is similar to control, however, the rate is higher in the mixed C57BL/6;129P2 and FVB/N backgrounds
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Background Sensitivity: the adult mortality rate is higher in mice on the mixed and FVB/N backgrounds, but not on the C57BL/6 background
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• Background Sensitivity: fewer homozygotes are produced in heterozygous x heterozygous matings
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• serum 17beta-estradiol levels are reduced prior to 6 weeks of age
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• delayed mammary gland development is observed in 5-6 week old females
• numbers of proliferating epithelial cells are reduced in the mammary glands from 5 week old females as compared to controls
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• mammary glands exhibit reduced numbers of terminal end buds, secondary branching and outgrowth length, however, differences disappear by 3 months of age
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• delayed mammary gland development is observed in 5-6 week old females
• numbers of proliferating epithelial cells are reduced in the mammary glands from 5 week old females as compared to controls
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• mammary glands exhibit reduced numbers of terminal end buds, secondary branching and outgrowth length, however, differences disappear by 3 months of age
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• uterine weight is decreased at 5-6 weeks, but is similar to controls by 7 weeks
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• females older than 3 months are infertile
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• pregnancy rate is lower in 6-12 week old females
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice weigh less than wild-type from pre weaning age to early adulthood
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• Background Sensitivity: the adult mortality rate is higher in mice on the mixed and FVB/N backgrounds, but not on the C57BL/6 background
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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