Phenotypes associated with this allele

• Allele Symbol: Map4k3^{Gt(RRO270)Byg}
• Allele Name: gene trap RRO270, BayGenomics
• Allele ID: MGI:4329479
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map4k3^Gt(RRO270)Byg/Map4k3^Gt(RRO270)Byg	involves: 129P2/OlaHsd	MGI:5297521

Genotype
MGI:5297521

hm1

• Allelic Composition: Map4k3^{Gt(RRO270)Byg}/Map4k3^{Gt(RRO270)Byg}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:177642 )

N

decreased T cell proliferation ( J:177642 )

abnormal T-helper 1 cell differentiation ( J:177642 )

• in vitro Th1 differentiation is reduced compared with wild-type cells

abnormal T-helper 2 cell differentiation ( J:177642 )

• in vitro Th2 differentiation is reduced compared with wild-type cells

abnormal T-helper 17 cell differentiation ( J:177642 )

• in vitro Th17 differentiation is reduced compared with wild-type cells

decreased immunoglobulin level ( J:177642 )

decreased IgG1 level ( J:177642 )

• NP-specific after first and second immunization

decreased IgG2a level ( J:177642 )

• NP-specific after first and second immunization

decreased IgG2b level ( J:177642 )

• NP-specific after first and second immunization

decreased IgG3 level ( J:177642 )

• NP-specific after first and second immunization

decreased IgM level ( J:177642 )

• NP-specific after first immunization

decreased interferon-gamma secretion ( J:177642 )

• from KLH-restimulated lymph node cells

abnormal interleukin secretion ( J:177642 )

decreased interleukin-17 secretion ( J:177642 )

• following induction of experimental autoimmune encephalomyelitis

decreased interleukin-2 secretion ( J:177642 )

• from KLH-restimulated lymph node cells

decreased interleukin-4 secretion ( J:177642 )

• from KLH-restimulated lymph node cells

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:177642 )

• with reduced inflammation and serum IL17 levels

hematopoietic system

decreased T cell proliferation ( J:177642 )

abnormal T-helper 1 cell differentiation ( J:177642 )

• in vitro Th1 differentiation is reduced compared with wild-type cells

abnormal T-helper 2 cell differentiation ( J:177642 )

• in vitro Th2 differentiation is reduced compared with wild-type cells

abnormal T-helper 17 cell differentiation ( J:177642 )

• in vitro Th17 differentiation is reduced compared with wild-type cells

decreased immunoglobulin level ( J:177642 )

decreased IgG1 level ( J:177642 )

• NP-specific after first and second immunization

decreased IgG2a level ( J:177642 )

• NP-specific after first and second immunization

decreased IgG2b level ( J:177642 )

• NP-specific after first and second immunization

decreased IgG3 level ( J:177642 )

• NP-specific after first and second immunization

decreased IgM level ( J:177642 )

• NP-specific after first immunization

cellular

decreased T cell proliferation ( J:177642 )