Analysis Tools
cellular
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• mutants show increased genomic instability
• MEFs exhibit increased frequency of DNA double-strand breaks as manifested by increased H2AX phosphorylation and more gamma-H2AX foci
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hematopoietic system
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• an increase in the rearrangement of the Igh mu-switch region
• however, no effect on immunoglobin class switch recombination is seen
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• mice show increased translocation between c-Myc and Igh loci in B cells
• doubling of R loop formation is seen at both the c-Myc locus and the Igh locus
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immune system
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• an increase in the rearrangement of the Igh mu-switch region
• however, no effect on immunoglobin class switch recombination is seen
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• mice show increased translocation between c-Myc and Igh loci in B cells
• doubling of R loop formation is seen at both the c-Myc locus and the Igh locus
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