Phenotypes associated with this allele

• Allele Symbol: Lrsam1^{Gt(RRK461)Byg}
• Allele Name: gene trap RRK461, BayGenomics
• Allele ID: MGI:4329496
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrsam1^Gt(RRK461)Byg/Lrsam1^Gt(RRK461)Byg	involves: 129P2/OlaHsd	MGI:5496257
ht2	Lrsam1^Gt(RRK461)Byg/Lrsam1^+	involves: 129P2/OlaHsd	MGI:5496260

Genotype
MGI:5496257

hm1

• Allelic Composition: Lrsam1^{Gt(RRK461)Byg}/Lrsam1^{Gt(RRK461)Byg}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axon morphology ( J:196447 )

• number of axons in the motor branch of the femoral nerve is slightly reduced at >12 months of age compared to controls, although cross-sectional area of axons is unchanged

• average axon diameter in the sensory branch of the femoral nerve is slightly increased at >12 months of age compared to controls

• 5 month old mice treated with the neurotoxic agent acrylamide have reduced axon cross-sectional areas in the motor branch of the femoral nerve, suggesting a loss of large diameter axons

abnormal neuromuscular synapse morphology ( J:196447 )

• area of neuromuscular junction of the tibialis anterior muscle is increased at 5 months of age, but is similar to control at > 12 months of age

axon degeneration ( J:196447 )

• peripheral motor axons exhibit increased sensitivity to acrylamide-induced degeneration

• untreated mice exhibit modest differences in neuromuscular junction area and axon number

decreased nerve conduction velocity ( J:196447 )

• decrease in nerve conduction velocity is observed in 5 month old mice treated with the neurotoxic agent acrylamide for two weeks

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Charcot-Marie-Tooth disease axonal type 2P		DOID:0110169	OMIM:614436	J:196447

Genotype
MGI:5496260

ht2

• Allelic Composition: Lrsam1^{Gt(RRK461)Byg}/Lrsam1⁺
• Genetic Background: involves: 129P2/OlaHsd

behavior/neurological

abnormal limb posture ( J:196447 )

• paws turn outward

• wider stance than control, however gait, stride time, stance time and swing time are similar to control

nervous system

abnormal axon morphology ( J:196447 )

• number of axons in the motor branch of the femoral nerve is slightly reduced at >12 months of age compared to controls, although cross-sectional area of axons is unchanged

• average axon diameter in the sensory branch of the femoral nerve is slightly decreased at >12 months of age compared to controls

• number of motor axons in the femoral nerve are reduced in 5 month old mice treated with the neurotoxic agent acrylamide

abnormal neuromuscular synapse morphology ( J:196447 )

• area of neuromuscular junction in the bone region of the tibialis anterior muscle is increased at 5 months of age, but is similar to control at > 12 months of age