Phenotypes associated with this allele

• Allele Symbol: Prep^{Gt(RRM213)Byg}
• Allele Name: gene trap RRM213, BayGenomics
• Allele ID: MGI:4329536
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prep^Gt(RRM213)Byg/Prep^Gt(RRM213)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:4355343
ht2	Prep^Gt(RRM213)Byg/Prep^+	B6.129P2-Prep^Gt(RRM213)Byg	MGI:4355345
ht3	Prep^Gt(RRM213)Byg/Prep^+	involves: 129P2/OlaHsd * C57BL/6	MGI:4355344

Genotype
MGI:4355343

hm1

• Allelic Composition: Prep^{Gt(RRM213)Byg}/Prep^{Gt(RRM213)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body mass index ( J:151643 )

♂ • in male mice fed a high fat diet

decreased body weight ( J:151643 )

• when fed a low fat diet, female mice weigh less than similarly treated wild-type mice

• when fed a high fat diet, male mice weigh less than similarly treated heterozygous mice

• however, body weight of mice on a high fat diet is the same as in wild-type mice

homeostasis/metabolism

increased circulating leptin level ( J:151643 )

♀ • in female mice when fed a high fat diet

renal/urinary system

decreased kidney weight ( J:151643 )

♀ • when fed a low fat diet, female mice exhibit lighter kidneys than in similarly treated wild-type mice

Genotype
MGI:4355345

ht2

• Allelic Composition: Prep^{Gt(RRM213)Byg}/Prep⁺
• Genetic Background: B6.129P2-Prep^{Gt(RRM213)Byg}

growth/size/body

increased body mass index ( J:151643 )

• when this allele is inherited maternally

increased body weight ( J:151643 )

• when this allele is inherited maternally, female mice fed a low fat diet weigh more than similarly treated wild-type mice

increased kidney weight ( J:151643 )

• when this allele is inherited maternally

increased liver weight ( J:151643 )

• when this allele is inherited maternally

increased spleen weight ( J:151643 )

• when this allele is inherited maternally

adipose tissue

increased percent body fat/body weight ( J:151643 )

• when this allele is inherited maternally, mice fed a low fat diet exhibit more adiposity than similarly treated wild-type mice

renal/urinary system

increased kidney weight ( J:151643 )

• when this allele is inherited maternally

immune system

increased spleen weight ( J:151643 )

• when this allele is inherited maternally

liver/biliary system

increased liver weight ( J:151643 )

• when this allele is inherited maternally

hematopoietic system

increased spleen weight ( J:151643 )

• when this allele is inherited maternally

Genotype
MGI:4355344

ht3

• Allelic Composition: Prep^{Gt(RRM213)Byg}/Prep⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

adipose tissue

decreased total body fat amount ( J:151643 )

• when fed a low fat diet, female mice exhibit reduced adiposity index (as measured by weight of four fat pads) compared with similarly treated wild-type mice

growth/size/body

increased body weight ( J:151643 )

• when fed a high fat diet, male mice weigh more than similarly treated homozygous mice

• however, body weight of mice on a high fat diet is the same as in wild-type mice