Analysis Tools
homeostasis/metabolism
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• fasted mice exhibit increased glyconeogenesis compared with wild-type mice
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• in the liver and kidney of fasted mice due to increased triglyceride hydrolysis and glyconeogenesis
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• in fasted mice
• however, basal levels in non-fasted mice are normal
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• in fasted mice
• however, basal levels in non-fasted mice are normal
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• fasted mice exhibit increased triglyceride hydrolysis compared with wild-type mice
• however, ketone levels are normal
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• in fasted, but not fed, mice
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• in fasted, but not fed, mice
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• in mice fed a high fat diet
• however, mice fed a normal diet exhibit normal levels
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renal/urinary system
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• in fasted mice
• however, basal levels in non-fasted mice are normal
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liver/biliary system
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• relative to body weight in fasted mice
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• in fasted mice
• however, basal levels in non-fasted mice are normal
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• in mice fed a high fat diet
• however, mice fed a normal diet exhibit normal levels
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• in fasted mice
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immune system
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• CD4+ T cells exhibit normal mitochondrial membrane potential and mitochondrial reactive oxygen species production
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• mitochondria in CD8 cells are hyperpolarized unlike in wild-type cells
• increased mitochondrial membrane potential in CD8 cells do not exhibit an increase in mitochondrial reactive oxygen species production unlike in wild-type cell
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cellular
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• increased complex I activity in the heart and CD8+ T cell mitochondria
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adipose tissue
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• fasted mice exhibit more prominent white fat loss compared with wild-type mice
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hematopoietic system
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• mitochondria in CD8 cells are hyperpolarized unlike in wild-type cells
• increased mitochondrial membrane potential in CD8 cells do not exhibit an increase in mitochondrial reactive oxygen species production unlike in wild-type cell
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growth/size/body
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• relative to body weight in fasted mice
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