Phenotypes associated with this allele

• Allele Symbol: Uimc1^{Gt(RRN158)Byg}
• Allele Name: gene trap RRN158, BayGenomics
• Allele ID: MGI:4329579
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Uimc1^Gt(RRN158)Byg/Uimc1^Gt(RRN158)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:5440673

Genotype
MGI:5440673

hm1

• Allelic Composition: Uimc1^{Gt(RRN158)Byg}/Uimc1^{Gt(RRN158)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased mortality induced by gamma-irradiation ( J:188388 )

decreased tumor-free survival time ( J:188388 )

• due to excessive tumor burden

• 49% of mice survive until 24 months compared with 79% of wild-type mice

cellular

increased cellular sensitivity to gamma-irradiation ( J:188388 )

• in mouse embryonic fibroblasts

abnormal DNA repair ( J:188388 )

• in mouse embryonic fibroblasts exposed to ionizing radiation

chromosome breakage ( J:188388 )

• in mouse embryonic fibroblasts exposed to ionizing radiation

neoplasm

increased tumor incidence ( J:188388 )

• 27 of 41 mice develop tumor compared with 8 of 24 control mice

increased B cell derived lymphoma incidence ( J:188388 )

• with increased mitotic index

homeostasis/metabolism

abnormal DNA repair ( J:188388 )

• in mouse embryonic fibroblasts exposed to ionizing radiation

increased mortality induced by gamma-irradiation ( J:188388 )