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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Eif4eGt(RRO036)Byg
gene trap RRO036, BayGenomics
MGI:4329663
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Eif4eGt(RRO036)Byg/Eif4e+
Krastm3Tyj/Kras+ 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N MGI:5708384


Genotype
MGI:5708384
cx1
Allelic
Composition		 Eif4eGt(RRO036)Byg/Eif4e+
Krastm3Tyj/Kras+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif4eGt(RRO036)Byg mutation (0 available); any Eif4e mutation (42 available)
Krastm3Tyj mutation (2 available); any Kras mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor growth/size ( J:224214 )
• smaller tumors of mice treated with piperlongumine than in Krastm3Tyj heterozygotes
decreased lung tumor incidence ( J:224214 )
• fewer tumors by 12 weeks with a more than 2-fold reduction in tumor burden compared with Krastm3Tyj heterozygotes

cellular
increased cellular sensitivity to oxidative stress ( J:224214 )
• in tumors of mice treated with piperlongumine
oxidative stress ( J:224214 )
• increased compared with Krastm3Tyj heterozygotes

respiratory system
decreased lung tumor incidence ( J:224214 )
• fewer tumors by 12 weeks with a more than 2-fold reduction in tumor burden compared with Krastm3Tyj heterozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory