Phenotypes associated with this allele

• Allele Symbol: Sptan1^{Gt(RRQ171)Byg}
• Allele Name: gene trap RRQ171, BayGenomics
• Allele ID: MGI:4330132
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sptan1^Gt(RRQ171)Byg/Sptan1^Gt(RRQ171)Byg	B6.129P2-Sptan1^Gt(RRQ171)Byg	MGI:5431892
hm2	Sptan1^Gt(RRQ171)Byg/Sptan1^Gt(RRQ171)Byg	involves: 129P2/OlaHsd	MGI:5431706

Genotype
MGI:5431892

hm1

• Allelic Composition: Sptan1^{Gt(RRQ171)Byg}/Sptan1^{Gt(RRQ171)Byg}
• Genetic Background: B6.129P2-Sptan1^{Gt(RRQ171)Byg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:186305 )

• mice die between E12.5 and E16.5

embryonic lethality during organogenesis, incomplete penetrance ( J:186305 )

• mice die between E12.5 and E16.5

nervous system

abnormal neural tube closure ( J:186305 )

• incomplete

cerebral aqueductal stenosis ( J:186305 )

• constriction of the mesencephalic vesicle

dilated brain ventricle ( J:186305 )

• dilatation of the primary brain vesicles

abnormal forebrain morphology ( J:186305 )

• forebrain anomalies

decreased cortical ventricular zone cell density ( J:186305 )

• the density of neuroepithelial cells along the ventricular zone is reduced compared to in wild-type mice

abnormal lateral ventricle morphology ( J:186305 )

• lateral ventricle anomalies

abnormal embryonic/fetal subventricular zone morphology ( J:186305 )

• mice exhibit increased nuclear density with more proliferating cells in the subventricular zone compared with wild-type mice

cardiovascular system

thin myocardium compact layer ( J:186305 )

abnormal heart shape ( J:186305 )

dilated heart ( J:186305 )

embryo

embryonic growth retardation ( J:186305 )

• reduced embryo length at E11.5

decreased embryo size ( J:186305 )

• reduced embryo length at E11.5

abnormal neural tube closure ( J:186305 )

• incomplete

cellular

abnormal cell physiology ( J:186305 )

• impaired cell spreading in mouse embryonic fibroblasts

increased cell proliferation ( J:186305 )

• in the subventricular zone

• in mouse embryonic fibroblasts

craniofacial

abnormal craniofacial morphology ( J:186305 )

growth/size/body

embryonic growth retardation ( J:186305 )

• reduced embryo length at E11.5

decreased embryo size ( J:186305 )

• reduced embryo length at E11.5

muscle

thin myocardium compact layer ( J:186305 )

Genotype
MGI:5431706

hm2

• Allelic Composition: Sptan1^{Gt(RRQ171)Byg}/Sptan1^{Gt(RRQ171)Byg}
• Genetic Background: involves: 129P2/OlaHsd

nervous system

abnormal axon initial segment morphology ( J:186168 )

• severely disrupted