Phenotypes associated with this allele

• Allele Symbol: Cttn^{Gt(RRS284)Byg}
• Allele Name: gene trap RRS284, BayGenomics
• Allele ID: MGI:4330257
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cttn^Gt(RRS284)Byg/Cttn^Gt(RRS284)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:4437715
ht2	Cttn^Gt(RRS284)Byg/Cttn^+	involves: 129P2/OlaHsd * C57BL/6	MGI:4437714

Genotype
MGI:4437715

hm1

• Allelic Composition: Cttn^{Gt(RRS284)Byg}/Cttn^{Gt(RRS284)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:158029 )

• zygotes die prior to the 2-cell stage

embryo

abnormal preimplantation embryo development ( J:158029 )

• 75% of zygotes exhibit either no second polar body or abnormal morphology such as significant cellular fragmentation compared with wild-type zygotes

failure of zygotic cell division ( J:158029 )

• zygotes die prior to the 2-cell stage

reproductive system

abnormal secondary polar body morphology ( J:158029 )

• 75% of zygotes exhibit either no second polar body or abnormal morphology

cellular

abnormal secondary polar body morphology ( J:158029 )

• 75% of zygotes exhibit either no second polar body or abnormal morphology

Genotype
MGI:4437714

ht2

• Allelic Composition: Cttn^{Gt(RRS284)Byg}/Cttn⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

reproductive system

transmission ratio distortion ( J:158029 )

• an increased proportion of embryos that expected is observed

cellular

abnormal cell morphology ( J:158029 )

• mouse embryonic fibroblasts exhibit impaired actin dynamics compared with wild-type cells