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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Arhgap21Gt(RRR629)Byg
gene trap RRR629, BayGenomics
MGI:4330478
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Arhgap21Gt(RRR629)Byg/Arhgap21Gt(RRR629)Byg B6.129P2-Arhgap21Gt(RRR629)Byg MGI:6196211
ht2
 		Arhgap21Gt(RRR629)Byg/Arhgap21+ B6.129P2-Arhgap21Gt(RRR629)Byg MGI:6196212


Genotype
MGI:6196211
hm1
Allelic
Composition		 Arhgap21Gt(RRR629)Byg/Arhgap21Gt(RRR629)Byg
Genetic
Background		 B6.129P2-Arhgap21Gt(RRR629)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgap21Gt(RRR629)Byg mutation (0 available); any Arhgap21 mutation (133 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:6196212
ht2
Allelic
Composition		 Arhgap21Gt(RRR629)Byg/Arhgap21+
Genetic
Background		 B6.129P2-Arhgap21Gt(RRR629)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgap21Gt(RRR629)Byg mutation (0 available); any Arhgap21 mutation (133 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased megakaryocyte cell number ( J:262703 )
• 2-fold increase in frequency
decreased erythroid progenitor cell number ( J:262703 )
• 2-fold decrease in the bone marrow and spleen
• however, late subtypes of erythroid differentiation is normal
increased leukocyte cell number ( J:262703 )
• however, the percentage of B220+ B lymphocytes and T lymphocytes are normal
abnormal hematopoietic stem cell physiology ( J:262703 )
• enhanced egress from the bone marrow with reduced fibronectin adhesion

homeostasis/metabolism
increased susceptibility to injury ( J:262703 )
• mice treated with 5-fluorouracil exhibit increased neutrophils likely due to increased hematopoietic stem cells but decreased colonies forming units (CFU-GEMM, combined number of CFU-GM, CFU-G and CFU-M, and BFU-E) in the bone marrow and hematocrit compared with wild-type mice

immune system
increased leukocyte cell number ( J:262703 )
• however, the percentage of B220+ B lymphocytes and T lymphocytes are normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory