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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ptpn14Gt(RRR484)Byg
gene trap RRR484, BayGenomics
MGI:4330561
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ptpn14Gt(RRR484)Byg/Ptpn14Gt(RRR484)Byg involves: 129P2/OlaHsd MGI:4941809


Genotype
MGI:4941809
hm1
Allelic
Composition		 Ptpn14Gt(RRR484)Byg/Ptpn14Gt(RRR484)Byg
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn14Gt(RRR484)Byg mutation (0 available); any Ptpn14 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
periorbital edema ( J:169186 )
• in 14% of mice after 5 months
lymphedema ( J:169186 )
• after 5 months, 14% of mice exhibit edema in the forelimb and/or hindlimb swelling unlike wild-type mice

growth/size/body
periorbital edema ( J:169186 )
• in 14% of mice after 5 months
decreased body weight ( J:169186 )
• until 6 months of age
abnormal postnatal growth ( J:169186 )
• until 6 months of age

immune system
lymphatic vessel hyperplasia ( J:169186 )
• in some mice due to leakiness of gene trap

craniofacial
craniofacial phenotype ( J:169186 )
N
• mice exhibit normal choanae development
periorbital edema ( J:169186 )
• in 14% of mice after 5 months




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory