All Phenotypes Dcun1d1<Gt(RRR261)Byg> MGI Mouse

endocrine/exocrine glands

seminiferous tubule degeneration ( J:270036 )

• degeneration phenotype is variable, ranging from sloughing into the lumen of the tubule to development of large vacuoles and a Sertoli cell only phenotype with complete loss of germ cells

testicular atrophy ( J:270036 )

immune system

spleen hypoplasia ( J:262901 )

lymphoid hypoplasia ( J:262901 )

reproductive system

asthenozoospermia ( J:270036 )

seminiferous tubule degeneration ( J:270036 )

• degeneration phenotype is variable, ranging from sloughing into the lumen of the tubule to development of large vacuoles and a Sertoli cell only phenotype with complete loss of germ cells

testicular atrophy ( J:270036 )

abnormal spermatogenesis ( J:270036 )

• asynchronous spermatogenesis, with multiple generations of developing spermatids in the same cross-section of the seminiferous tubule

oligozoospermia ( J:270036 )

• reduced numbers of sperm within the epididymis

teratozoospermia ( J:270036 )

abnormal sperm flagellum morphology ( J:270036 )

abnormal sperm head morphology ( J:270036 )

globozoospermia ( J:270036 )

abnormal spermiogenesis ( J:270036 )

male infertility ( J:270036 )

mortality/aging

decreased survivor rate ( J:270036 )

• reduced viability postnatally, with reduced numbers by weaning age

growth/size/body

decreased body size ( J:262901 , J:270036 )

• however, cell size in organs is normal (J:262901)

• runting at postnatal stages (J:270036)

cellular