Phenotypes associated with this allele

• Allele Symbol: Ccnt1^{Gt(RRR115)Byg}
• Allele Name: gene trap RRR115, BayGenomics
• Allele ID: MGI:4330764
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccnt1^Gt(RRR115)Byg/Ccnt1^Gt(RRR115)Byg	involves: 129P2/OlaHsd	MGI:7488343

Genotype
MGI:7488343

hm1

• Allelic Composition: Ccnt1^{Gt(RRR115)Byg}/Ccnt1^{Gt(RRR115)Byg}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:130071 )

N • mice exhibit normal numbers of B and T cells, with an appropriate ratio of CD4+ and CD8+ cells; these cells lack activation markers

salivary gland inflammation ( J:130071 )

• less than half of 5- to 7-month-old mice analyzed exhibit a relatively mild lymphocytic infiltration of salivary glands

abnormal thymus physiology ( J:130071 )

• mice do not express AIRE-responsive genes in the thymus; protein levels of HEXIM1 (hexamethylene bis-acetamide inducible 1) and CDK9 (cyclin dependent kinase 9) are reduced in the thymus

• primary medullary thymic epithelial cells (mTECs) show significantly lower mRNA levels of Mucl2 (mucin-like 2; aka Spt1, salivary protein 1) and Ins2 (insulin II) than wild-type mTECs

• however, mRNA levels of Aire [autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)] are normal in mTECs

lacrimal gland inflammation ( J:130071 )

• less than half of 5- to 7-month-old mice analyzed exhibit a relatively mild lymphocytic infiltration of lacrimal glands

autoimmune response ( J:130071 )

• mice exhibit lymphocytic infiltration in endocrine organs, resembling the autoimmune phenotypes seen in Aire^tm1.1Doi homozygotes

endocrine/exocrine glands

salivary gland inflammation ( J:130071 )

• less than half of 5- to 7-month-old mice analyzed exhibit a relatively mild lymphocytic infiltration of salivary glands

abnormal thymus physiology ( J:130071 )

• mice do not express AIRE-responsive genes in the thymus; protein levels of HEXIM1 (hexamethylene bis-acetamide inducible 1) and CDK9 (cyclin dependent kinase 9) are reduced in the thymus

• primary medullary thymic epithelial cells (mTECs) show significantly lower mRNA levels of Mucl2 (mucin-like 2; aka Spt1, salivary protein 1) and Ins2 (insulin II) than wild-type mTECs

• however, mRNA levels of Aire [autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)] are normal in mTECs

lacrimal gland inflammation ( J:130071 )

• less than half of 5- to 7-month-old mice analyzed exhibit a relatively mild lymphocytic infiltration of lacrimal glands

hematopoietic system

abnormal thymus physiology ( J:130071 )

• mice do not express AIRE-responsive genes in the thymus; protein levels of HEXIM1 (hexamethylene bis-acetamide inducible 1) and CDK9 (cyclin dependent kinase 9) are reduced in the thymus

• primary medullary thymic epithelial cells (mTECs) show significantly lower mRNA levels of Mucl2 (mucin-like 2; aka Spt1, salivary protein 1) and Ins2 (insulin II) than wild-type mTECs

• however, mRNA levels of Aire [autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)] are normal in mTECs

digestive/alimentary system

salivary gland inflammation ( J:130071 )

• less than half of 5- to 7-month-old mice analyzed exhibit a relatively mild lymphocytic infiltration of salivary glands

vision/eye

lacrimal gland inflammation ( J:130071 )

• less than half of 5- to 7-month-old mice analyzed exhibit a relatively mild lymphocytic infiltration of lacrimal glands