Phenotypes associated with this allele

• Allele Symbol: Nampt^{Gt(RRR084)Byg}
• Allele Name: gene trap RRR084, BayGenomics
• Allele ID: MGI:4330782
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nampt^Gt(RRR084)Byg/Nampt^Gt(RRR084)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:5474951
ht2	Nampt^Gt(RRR084)Byg/Nampt^+	involves: 129P2/OlaHsd * C57BL/6	MGI:5474950

Genotype
MGI:5474951

hm1

• Allelic Composition: Nampt^{Gt(RRR084)Byg}/Nampt^{Gt(RRR084)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:194883 )

• no mice are produced from breeding heterozygous mice

Genotype
MGI:5474950

ht2

• Allelic Composition: Nampt^{Gt(RRR084)Byg}/Nampt⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

immune system

decreased neutrophil cell number ( J:194883 )

• in the bronchoalveolar lavage fluid of mice subjected to ventilator-induced lung injury

decreased interleukin-6 secretion ( J:194883 )

• in the bronchoalveolar lavage fluid of mice subjected to ventilator-induced lung injury

homeostasis/metabolism

decreased susceptibility to injury ( J:194883 )

• mice subjected to ventilator-induced lung injury exhibit decreased inflammatory lung injury and lower peak inspiratory pressures at the end of the mechanical ventilation period compared with wild-type mice

hematopoietic system

decreased neutrophil cell number ( J:194883 )

• in the bronchoalveolar lavage fluid of mice subjected to ventilator-induced lung injury