All Phenotypes Mcm3<Gt(RRR002)Byg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mcm3^{Gt(RRR002)Byg}
gene trap RRR002, BayGenomics
MGI:4330835

Summary

14 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mcm3^{Gt(RRR002)Byg}/Mcm3^{Gt(RRR002)Byg}	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838131
ht2	Mcm3^{Gt(RRR002)Byg}/Mcm3⁺	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838130
cx3	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838120
cx4	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^{Gt(RRE056)Byg}/Mcm4⁺	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838122
cx5	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838123
cx6	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺ Mcm7^{Gt(YTA285)Byg}/Mcm7⁺	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838124
cx7	Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^{Gt(RRE056)Byg}/Mcm4⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838126
cx8	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^{Gt(RRE056)Byg}/Mcm4⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838127
cx9	Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^{Gt(RRE056)Byg}/Mcm4⁺	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838129
cx10	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^{Gt(RRE056)Byg}/Mcm4⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺ Mcm7^{Gt(YTA285)Byg}/Mcm7⁺	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838137
cx11	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^chaos3/Mcm4^chaos3	involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J	MGI:4838110
cx12	Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^chaos3/Mcm4^{Gt(RRE056)Byg}	involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J	MGI:4838113
cx13	Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^chaos3/Mcm4^chaos3 Mcm6^{Gt(YHD248)Byg}/Mcm6⁺	involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J	MGI:4838114
cx14	Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^chaos3/Mcm4^chaos3	involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J	MGI:4838115

Allelic Composition	Mcm3^{Gt(RRR002)Byg}/Mcm3^{Gt(RRR002)Byg}
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm3^{Gt(RRR002)Byg} mutation (0 available); any Mcm3 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:165667 )

• no viable mice are present at birth

Allelic Composition	Mcm3^{Gt(RRR002)Byg}/Mcm3⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm3^{Gt(RRR002)Byg} mutation (0 available); any Mcm3 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

Allelic Composition	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

Allelic Composition	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^{Gt(RRE056)Byg}/Mcm4⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

Allelic Composition	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

Allelic Composition	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺ Mcm7^{Gt(YTA285)Byg}/Mcm7⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2^{Gt(AB0178)Wtsi} mutation (0 available); any Mcm2 mutation (51 available)
Mcm3^{Gt(RRR002)Byg} mutation (0 available); any Mcm3 mutation (43 available)
Mcm6^{Gt(YHD248)Byg} mutation (0 available); any Mcm6 mutation (37 available)
Mcm7^{Gt(YTA285)Byg} mutation (0 available); any Mcm7 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

Allelic Composition	Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^{Gt(RRE056)Byg}/Mcm4⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm3^{Gt(RRR002)Byg} mutation (0 available); any Mcm3 mutation (43 available)
Mcm4^{Gt(RRE056)Byg} mutation (0 available); any Mcm4 mutation (43 available)
Mcm6^{Gt(YHD248)Byg} mutation (0 available); any Mcm6 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

Allelic Composition	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^{Gt(RRE056)Byg}/Mcm4⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2^{Gt(AB0178)Wtsi} mutation (0 available); any Mcm2 mutation (51 available)
Mcm3^{Gt(RRR002)Byg} mutation (0 available); any Mcm3 mutation (43 available)
Mcm4^{Gt(RRE056)Byg} mutation (0 available); any Mcm4 mutation (43 available)
Mcm6^{Gt(YHD248)Byg} mutation (0 available); any Mcm6 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

Allelic Composition	Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^{Gt(RRE056)Byg}/Mcm4⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

Allelic Composition	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^{Gt(RRE056)Byg}/Mcm4⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺ Mcm7^{Gt(YTA285)Byg}/Mcm7⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2^{Gt(AB0178)Wtsi} mutation (0 available); any Mcm2 mutation (51 available)
Mcm3^{Gt(RRR002)Byg} mutation (0 available); any Mcm3 mutation (43 available)
Mcm4^{Gt(RRE056)Byg} mutation (0 available); any Mcm4 mutation (43 available)
Mcm6^{Gt(YHD248)Byg} mutation (0 available); any Mcm6 mutation (37 available)
Mcm7^{Gt(YTA285)Byg} mutation (0 available); any Mcm7 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

Allelic Composition	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^chaos3/Mcm4^chaos3
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:165667 )

• lifespan is expanded compared to in Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm4^chaos3/Mcm4^chaos3 mice but all mice die by 12 months of age

postnatal lethality, incomplete penetrance ( J:165667 )

• mortality observed in Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm4^chaos3/Mcm4^chaos3 mice is largely rescued

neoplasm

increased tumor incidence ( J:165667 )

• onset of tumorigenesis (lymphoma, thymoma, bone tumors, and liver tumors) is delayed or eliminated compared with Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm4^chaos3/Mcm4^chaos3 mice

hematopoietic system

hematopoietic system phenotype ( J:165667 )

N	• the ratio of CD71+ reticulocytes to total red blood cells is completely corrected compared to in Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm4^chaos3/Mcm4^chaos3 mice

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with Mcm4^chaos3 homozygotes

cellular

decreased fibroblast proliferation ( J:165667 )

• mouse embryonic fibroblast proliferation (MEFs) is partially rescued compared to in Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm4^chaos3/Mcm4^chaos3 MEFs

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with Mcm4^chaos3 homozygotes

embryo

abnormal pluripotent precursor cell morphology ( J:165667 )

• mouse embryonic fibroblasts exhibit compromised ability to form induced pluripotent stem cells compared with Mcm4^chaos3/Mcm4^chaos3 cells but improved 2.5- to 10-fold compared with Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm4^chaos3/Mcm4^chaos3 cells

growth/size/body

growth/size/body region phenotype ( J:165667 )

N	• body weight is rescued compared with Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm4^chaos3/Mcm4^chaos3 mice

Allelic Composition	Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^chaos3/Mcm4^{Gt(RRE056)Byg}
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm3^{Gt(RRR002)Byg} mutation (0 available); any Mcm3 mutation (43 available)
Mcm4^chaos3 mutation (1 available); any Mcm4 mutation (43 available)
Mcm4^{Gt(RRE056)Byg} mutation (0 available); any Mcm4 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:165667 )

• mice die sooner than Mcm4^chaos3 homozygotes

postnatal lethality, incomplete penetrance ( J:165667 )

• postnatal mortality observed in Mcm4^chaos3/Mcm4^{Gt(RRE056)Byg} mice is partially rescued

neoplasm

increased mammary gland tumor incidence ( J:165667 )

increased lymphoma incidence ( J:165667 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:165667 )

integument

increased mammary gland tumor incidence ( J:165667 )

Allelic Composition	Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^chaos3/Mcm4^chaos3 Mcm6^{Gt(YHD248)Byg}/Mcm6⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm3^{Gt(RRR002)Byg} mutation (0 available); any Mcm3 mutation (43 available)
Mcm4^chaos3 mutation (1 available); any Mcm4 mutation (43 available)
Mcm6^{Gt(YHD248)Byg} mutation (0 available); any Mcm6 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:165667 )

• mortality observed in Mcm4^chaos3/Mcm4^chaos3 Mcm6^{Gt(YHD248)Byg}/Mcm6⁺ mice is partially rescued

neoplasm

increased tumor incidence ( J:165667 )

• tumor latency is shorted than in Mcm4^chaos3 homozygotes

increased lymphoma incidence ( J:165667 )

Allelic Composition	Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^chaos3/Mcm4^chaos3
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:165667 )

• onset of mammary gland tumorigenesis is delayed or eliminated compared with Mcm4^chaos3 homozygotes

mortality/aging

mortality/aging ( J:165667 )

N	• lifespan is expanded compared to in Mcm4^chaos3 homozygotes

neoplasm

neoplasm ( J:165667 )

N	• mice do not develop lymphomas or thymomas unlike Mcm4^chaos3 homozygotes

increased mammary gland tumor incidence ( J:165667 )

• onset of mammary gland tumorigenesis is delayed or eliminated compared with Mcm4^chaos3 homozygotes

integument

increased mammary gland tumor incidence ( J:165667 )

• onset of mammary gland tumorigenesis is delayed or eliminated compared with Mcm4^chaos3 homozygotes

embryo

abnormal pluripotent precursor cell morphology ( J:165667 )

• mouse embryonic fibroblasts exhibit increased ability to form induced pluripotent stem cells compared with Mcm4^chaos3/Mcm4^chaos3 cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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