All Phenotypes Grhl2<Gt(AC0205)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Grhl2^{Gt(AC0205)Wtsi}
gene trap AC0205, Wellcome Trust Sanger Institute
MGI:4331210

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grhl2^{Gt(AC0205)Wtsi}/Grhl2^{Gt(AC0205)Wtsi}	involves: 129P2/OlaHsd * BALB/c * C57BL/6	MGI:4948893
hm2	Grhl2^{Gt(AC0205)Wtsi}/Grhl2^{Gt(AC0205)Wtsi}	involves: 129P2/OlaHsd * C57BL/6	MGI:4948892
ht3	Grhl2^{Gt(AC0205)Wtsi}/Grhl2⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:4948891
cx4	Axd/Axd⁺ Grhl2^{Gt(AC0205)Wtsi}/Grhl2⁺	involves: 129P2/OlaHsd * BALB/c * C3H/HeN * C57BL/6	MGI:4948894

Allelic Composition	Grhl2^{Gt(AC0205)Wtsi}/Grhl2^{Gt(AC0205)Wtsi}
Genetic Background	involves: 129P2/OlaHsd * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl2^{Gt(AC0205)Wtsi} mutation (0 available); any Grhl2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:170759 )

• Background Sensitivity: mice are recovered at E10.5 unlike on a background lacking BALB/c where mice are not recovered after E9.5

nervous system

abnormal neural tube closure ( J:170759 )

• at E10.5, homozygotes exhibit neural tube closure defects at both rostral and caudal levels of the body axis

incomplete rostral neuropore closure ( J:170759 )

• at E10.5-11.5, all homozygotes exhibit cranial neural tube closure defects

spina bifida ( J:170759 )

• at E10.5-11.5, 88% of homozygotes exhibit spina bifida

exencephaly ( J:170759 )

• at E10.5, homozygotes exhibit severe exencephaly

craniofacial

facial cleft ( J:170759 )

• at E10.5, homozygotes exhibit a 'split face' phenotype

embryo

abnormal neural tube closure ( J:170759 )

• at E10.5, homozygotes exhibit neural tube closure defects at both rostral and caudal levels of the body axis

incomplete rostral neuropore closure ( J:170759 )

• at E10.5-11.5, all homozygotes exhibit cranial neural tube closure defects

spina bifida ( J:170759 )

• at E10.5-11.5, 88% of homozygotes exhibit spina bifida

growth/size/body

facial cleft ( J:170759 )

• at E10.5, homozygotes exhibit a 'split face' phenotype

Allelic Composition	Grhl2^{Gt(AC0205)Wtsi}/Grhl2^{Gt(AC0205)Wtsi}
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl2^{Gt(AC0205)Wtsi} mutation (0 available); any Grhl2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:170759 )

• Background Sensitivity: no homozygotes are recovered after E9.5, unlike on a background that also involves BALB/c where mice are recovered at E10.5

Allelic Composition	Grhl2^{Gt(AC0205)Wtsi}/Grhl2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl2^{Gt(AC0205)Wtsi} mutation (0 available); any Grhl2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

incomplete rostral neuropore closure ( J:170759 )

• at E9.5-10.5, 15% of heterozygotes exhibit cranial neural tube defects, involving failure of closure of the neural folds in the forebrain ('split face') and throughout the midbrain

nervous system

incomplete rostral neuropore closure ( J:170759 )

• at E9.5-10.5, 15% of heterozygotes exhibit cranial neural tube defects, involving failure of closure of the neural folds in the forebrain ('split face') and throughout the midbrain

exencephaly ( J:170759 )

craniofacial

facial cleft ( J:170759 )

growth/size/body

facial cleft ( J:170759 )

Allelic Composition	Axd/Axd⁺ Grhl2^{Gt(AC0205)Wtsi}/Grhl2⁺
Genetic Background	involves: 129P2/OlaHsd * BALB/c * C3H/HeN * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Axd mutation (1 available); any Axd mutation (1 available)
Grhl2^{Gt(AC0205)Wtsi} mutation (0 available); any Grhl2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

delayed neural tube closure ( J:170759 )

• 6 of 35 embryos show complete posterior neuropore closure by the 30-34 somite stage versus none of 17 stage-matched Axd heterozygous embryos, indicating amelioration of the delayed PNP closure phenotype

abnormal caudal neuropore morphology ( J:170759 )

• at the 30-31 and 32-34 somite stages, mice exhibit a significant reduction in the mean posterior neuropore length relative to Axd heterozygous embryos

nervous system

delayed neural tube closure ( J:170759 )

abnormal caudal neuropore morphology ( J:170759 )

• at the 30-31 and 32-34 somite stages, mice exhibit a significant reduction in the mean posterior neuropore length relative to Axd heterozygous embryos

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