Phenotypes associated with this allele

• Allele Symbol: Csad^{Gt(XP0392)Wtsi}
• Allele Name: gene trap XP0392, Wellcome Trust Sanger Institute
• Allele ID: MGI:4331536
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Csad^Gt(XP0392)Wtsi/Csad^Gt(XP0392)Wtsi	involves: 129P2/OlaHsd * C57BL/6J	MGI:5707281

Genotype
MGI:5707281

hm1

• Allelic Composition: Csad^{Gt(XP0392)Wtsi}/Csad^{Gt(XP0392)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:226734 )

• deaths occur within 24 hours

• 15% of pups from mating of the second homozygous generation survive

• 10% of pups from mating of the third homozygous generation survive

• cross fostering pups to wild type parents fails to improve survival

• taurine supplement given to parents before mating and through weaning restores survival rates

reproductive system

reproductive system phenotype ( J:226734 )

N • expected Mendelian ratios from heterozygous matings

N • pregnancy rates from matings of the first three homozygous generations are normal

N • rate of live births is normal

behavior/neurological

behavior/neurological phenotype ( J:226734 )

N • second generation homozygous females are good nurses when wild type pups are cross fostered to them