Phenotypes associated with this allele

• Allele Symbol: Klf3^{Gt(XS0187)Wtsi}
• Allele Name: gene trap XS0187, Wellcome Trust Sanger Institute
• Allele ID: MGI:4331780
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klf3^Gt(XS0187)Wtsi/Klf3^Gt(XS0187)Wtsi	involves: 129P2/OlaHsd * C57BL/6	MGI:5568083
ht2	Klf3^Gt(XS0187)Wtsi/Klf3^+	involves: 129P2/OlaHsd * C57BL/6	MGI:5568082

Genotype
MGI:5568083

hm1

• Allelic Composition: Klf3^{Gt(XS0187)Wtsi}/Klf3^{Gt(XS0187)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Thickening of the valve leaflets in Klf3^{Gt(XS0187)Wtsi}/Klf3^{Gt(XS0187)Wtsi} mice with aortic valvular stenosis

mortality/aging

preweaning lethality, incomplete penetrance ( J:206507 )

• fewer than expected mice are present at weaning

cardiovascular system

cardiovascular system phenotype ( J:206507 )

N • unlike mice heterozygous for an ENU-induce allele, mice do not exhibit septal defects

increased heart right atrium size ( J:206507 )

• increased right atrial area

increased heart weight ( J:206507 )

• in 2 of 7 mice

thick aortic valve cusps ( J:206507 )

aortic valve stenosis ( J:206507 )

increased heart right ventricle size ( J:206507 )

increased cardiac output ( J:206507 )

tricuspid valve regurgitation ( J:206507 )

pulmonary valve regurgitation ( J:206507 )

• in 5 of 7 mice

adipose tissue

decreased abdominal fat pad weight ( J:206507 )

growth/size/body

increased heart weight ( J:206507 )

• in 2 of 7 mice

decreased body weight ( J:206507 )

increased kidney weight ( J:206507 )

increased lung weight ( J:206507 )

increased liver weight ( J:206507 )

increased spleen weight ( J:206507 )

hematopoietic system

hematopoietic system phenotype ( J:206507 )

N • unlike mice heterozygous for an ENU-induce allele, mice exhibit normal red blood cell counts and hemoglobin concentration

increased spleen weight ( J:206507 )

increased red blood cell distribution width ( J:206507 )

increased leukocyte cell number ( J:206507 )

reticulocytosis ( J:206507 )

liver/biliary system

increased liver weight ( J:206507 )

nervous system

increased brain weight ( J:206507 )

renal/urinary system

increased kidney weight ( J:206507 )

respiratory system

increased lung weight ( J:206507 )

immune system

increased spleen weight ( J:206507 )

increased leukocyte cell number ( J:206507 )

Genotype
MGI:5568082

ht2

• Allelic Composition: Klf3^{Gt(XS0187)Wtsi}/Klf3⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

mortality/aging ( J:206507 )

N • unlike mice heterozygous for an ENU-induce allele, mice exhibit normal survival