Phenotypes associated with this allele

• Allele Symbol: Rif1^{Gt(XT0278)Wtsi}
• Allele Name: gene trap XT0278, Wellcome Trust Sanger Institute
• Allele ID: MGI:4331936
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rif1^Gt(XT0278)Wtsi/Rif1^Gt(XT0278)Wtsi	involves: 129P2/OlaHsd * CD-1 * MF1	MGI:5494854
hm2	Rif1^Gt(XT0278)Wtsi/Rif1^Gt(XT0278)Wtsi	involves: 129P2/OlaHsd * MF1	MGI:5494853
cx3	Rif1^Gt(XT0278)Wtsi/Rif1^Gt(XT0278)Wtsi Trp53bp1^tm1Jc/Trp53bp1^tm1Jc	involves: 129P2/OlaHsd * CD-1 * MF1	MGI:5494855

Genotype
MGI:5494854

hm1

• Allelic Composition: Rif1^{Gt(XT0278)Wtsi}/Rif1^{Gt(XT0278)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * CD-1 * MF1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:195061 )

♀ • no live female pups are recovered

preweaning lethality, incomplete penetrance ( J:195061 )

♂ • fewer than expected mice are recovered

immune system

immune system phenotype ( J:195061 )

♂N • mice exhibit normal lymphocyte development and B cell proliferation

abnormal class switch recombination ( J:195061 )

♂ • impaired when stimulated with LPS or anti-mouse CD40 with or without IL4

decreased IgA level ( J:195061 )

♂ • in unstimulated mice

decreased IgG level ( J:195061 )

♂ • in unstimulated and NP-KLH-stimulated mice

decreased IgG1 level ( J:195061 )

♂ • in unstimulated and NP-KLH-stimulated mice

decreased IgG2b level ( J:195061 )

♂ • in unstimulated and NP-KLH-stimulated mice

decreased IgG3 level ( J:195061 )

♂ • in unstimulated mice

increased susceptibility to bacterial infection ( J:195061 )

♂ • in some mice infected with Staphylococcous xylosus

cellular

increased cellular sensitivity to ionizing radiation ( J:195061 )

♂ • in mouse embryonic fibroblasts

abnormal DNA repair ( J:195061 )

♂ • mouse embryonic fibroblasts exhibit suppression of chromosome end fusion events at telomeres induced by expression of a dominant negative Terf2

abnormal double-strand DNA break repair ( J:195061 )

♂ • hyperresection in mouse embryonic fibroblasts following irradiation treatment or during class switch recombination

homeostasis/metabolism

abnormal DNA repair ( J:195061 )

♂ • mouse embryonic fibroblasts exhibit suppression of chromosome end fusion events at telomeres induced by expression of a dominant negative Terf2

abnormal double-strand DNA break repair ( J:195061 )

♂ • hyperresection in mouse embryonic fibroblasts following irradiation treatment or during class switch recombination

hematopoietic system

abnormal class switch recombination ( J:195061 )

♂ • impaired when stimulated with LPS or anti-mouse CD40 with or without IL4

decreased IgA level ( J:195061 )

♂ • in unstimulated mice

decreased IgG level ( J:195061 )

♂ • in unstimulated and NP-KLH-stimulated mice

decreased IgG1 level ( J:195061 )

♂ • in unstimulated and NP-KLH-stimulated mice

decreased IgG2b level ( J:195061 )

♂ • in unstimulated and NP-KLH-stimulated mice

decreased IgG3 level ( J:195061 )

♂ • in unstimulated mice

Genotype
MGI:5494853

hm2

• Allelic Composition: Rif1^{Gt(XT0278)Wtsi}/Rif1^{Gt(XT0278)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * MF1

mortality/aging

preweaning lethality, complete penetrance ( J:195061 )

• while present at E7.5, no live pups are recovered

embryo

embryonic growth retardation ( J:195061 )

• at E7.5

growth/size/body

embryonic growth retardation ( J:195061 )

• at E7.5

Genotype
MGI:5494855

cx3

• Allelic Composition: Rif1^{Gt(XT0278)Wtsi}/Rif1^{Gt(XT0278)Wtsi}; Trp53bp1^tm1Jc/Trp53bp1^tm1Jc
• Genetic Background: involves: 129P2/OlaHsd * CD-1 * MF1

cellular

increased cellular sensitivity to ionizing radiation ( J:195061 )

♂ • in mouse embryonic fibroblasts (MEFs) as in MEFs from Rif1^{Gt(XT0278)Wtsi} homozygotes