Analysis Tools|
Allele Symbol Allele Name Allele ID |
Kmt2dGt(RRT024)Byg gene trap RRT024, BayGenomics MGI:4332076 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• embryonic lethality by E12
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit low levels of body fat mass
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• mice exhibit resistance to high-fat diet-induced obesity
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• dwarfism
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• mice are lighter after 11 weeks of age
(J:301497)
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• reduction in linear length
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• marker analysis shows a reduction in growth hormone-releasing hormone (GHRH) producing neurons
• however, proopiemlanocortin (POMC)-neuron numbers are normal and agouti-related peptide (agRP)-neurons are mildly increased
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• mice exhibit low levels of body fat mass
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• mice exhibit resistance to high-fat diet-induced obesity
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• mice exhibit increased serum and feces bile acid levels
• both serum and hepatic bile acid levels are increased during daytime, resulting in a loss of rhythmic fluctuation of bile acid levels over the circadian cycle
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Kabuki syndrome | DOID:0060473 |
OMIM:147920 OMIM:300867 |
J:301083 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice show deficits in contextual fear conditioning
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• mice show deficits in novel object recognition
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• mice show deficits in the Morris water maze probe trial
• however, mice do not show decreased activity, reduced grip strength, or slower swim speeds or differences in the escape latency during the training phase of the Morris water maze
• mice treated with the histone deacetylase inhibitor (HDACi) AR-42 beginning at 20 weeks of age and continuing for 2 weeks show improvement of hippocampal memory defects
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• flattened snout
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• flattened snout
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• decrease in body weight, however no decrease in brain weight is seen
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• downward rotation of the ear canal
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• reduction in dentate gyrus granule cell layer
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• reduction in dentate gyrus granule cell layer
• reduction in neurogenesis in the granule cell layer as evidenced by reduced expression of doublecortin and EdU staining
• decrease in dendritic branching complexity of doublecortin-positive cells in the granule cell layer
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Kabuki syndrome | DOID:0060473 |
OMIM:147920 OMIM:300867 |
J:225779 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit decreased body fat mass percentage at 15 weeks of age
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• mice exhibit decreased body weight at 7 weeks of age
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• mice exhibit decreased body fat mass percentage at 15 weeks of age
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• mice exhibit increased serum bile acid levels
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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