Phenotypes associated with this allele

• Allele Symbol: Appl1^{Gt(RRS819)Byg}
• Allele Name: gene trap RRS819, BayGenomics
• Allele ID: MGI:4332126
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Appl1^Gt(RRS819)Byg/Appl1^Gt(RRS819)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:5789933

Genotype
MGI:5789933

hm1

• Allelic Composition: Appl1^{Gt(RRS819)Byg}/Appl1^{Gt(RRS819)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:211794 )

♂N • normal oxygen consumption, respiratory quotient, and insulin, adiponectin, leptin and lipid (cholesterol, HDL, triglyceride, free fatty acid) levels under fed conditions

increased fasting circulating glucose level ( J:211794 )

♂ • significantly higher plasma glucose levels under fasting conditions relative to wild-type controls

increased circulating insulin level ( J:211794 )

♂ • significantly higher plasma insulin levels under fasting conditions relative to wild-type controls

♂ • however, normal plasma insulin levels under fed conditions

increased core body temperature ( J:211794 )

♂ • significantly higher core body temperature relative to wild-type controls

impaired glucose tolerance ( J:211794 )

♂ • impaired glucose tolerance in glucose tolerance test (GTT)

abnormal hepatic glucose production ( J:211794 )

♂ • significant reduction in hepatic glucose production (HGP) suppression (% of basal HGP) during hyperinsulinemic-euglycemic clamp relative to wild-type controls

insulin resistance ( J:211794 )

♂ • reduced insulin and adiponectin signaling leading to systemic insulin resistance

♂ • impaired insulin tolerance in insulin tolerance test (ITT)

♂ • significant reductions in glucose infusion rate, total glucose disposal, and insulin-mediated suppression of hepatic glucose production during the hyperinsulinemic-euglycemic clamp relative to wild-type controls

behavior/neurological

behavior/neurological phenotype ( J:211794 )

♂N • normal food intake monitored weekly for 24 weeks under normal chow conditions

hyperactivity ( J:211794 )

♂ • significantly increased activity during the dark cycle relative to wild-type controls

adipose tissue

abnormal brown adipose tissue physiology ( J:211794 )

♂ • enhanced UCP-1 expression in brown fat tissues relative to wild-type controls

growth/size/body

growth/size/body region phenotype ( J:211794 )

♂N • normal body weight and percentage tissue weight of body weight under normal chow conditions at 32 weeks of age