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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Usp25Gt(RRS805)Byg
gene trap RRS805, BayGenomics
MGI:4332130
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Usp25Gt(RRS805)Byg/Usp25Gt(RRS805)Byg involves: 129P2/OlaHsd MGI:5446808


Genotype
MGI:5446808
hm1
Allelic
Composition
Usp25Gt(RRS805)Byg/Usp25Gt(RRS805)Byg
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Usp25Gt(RRS805)Byg mutation (0 available); any Usp25 mutation (75 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in an model of IL17-induced pulmonary inflammation
• fewer IFNG-producing splenocytes in MOG-treated mice
• in the bronchoalveolar lavage fluid of mice treated with IL17
• MOG-treated mice exhibit exacerbated experimental autoimmune encephalomyelitis with greater clinical severity and increased macrophages and neutrophils in the central nervous system compared with wild-type mice
• however, production of IL2 and IL17 is normal
• mice treated with IL17 exhibit increased pulmonary inflammation, increased neutrophils and secretion of IL6 and CXCL1 into the bronchoalveolar lavage fluid compared with wild-type mice

respiratory system
• mice treated with IL17 exhibit increased pulmonary inflammation, increased neutrophils and secretion of IL6 and CXCL1 into the bronchoalveolar lavage fluid compared with wild-type mice

hematopoietic system
• in an model of IL17-induced pulmonary inflammation





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory