immune system
• in an model of IL17-induced pulmonary inflammation
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• fewer IFNG-producing splenocytes in MOG-treated mice
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• in the bronchoalveolar lavage fluid of mice treated with IL17
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• MOG-treated mice exhibit exacerbated experimental autoimmune encephalomyelitis with greater clinical severity and increased macrophages and neutrophils in the central nervous system compared with wild-type mice
• however, production of IL2 and IL17 is normal
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• mice treated with IL17 exhibit increased pulmonary inflammation, increased neutrophils and secretion of IL6 and CXCL1 into the bronchoalveolar lavage fluid compared with wild-type mice
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respiratory system
• mice treated with IL17 exhibit increased pulmonary inflammation, increased neutrophils and secretion of IL6 and CXCL1 into the bronchoalveolar lavage fluid compared with wild-type mice
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hematopoietic system
• in an model of IL17-induced pulmonary inflammation
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