Phenotypes associated with this allele

• Allele Symbol: Sugt1^{Gt(RRS405)Byg}
• Allele Name: gene trap RRS405, BayGenomics
• Allele ID: MGI:4332293
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sugt1^Gt(RRS405)Byg/Sugt1^Gt(RRS405)Byg	involves: 129P2/OlaHsd * C57BL/6J	MGI:5696983
cx2	Sugt1^Gt(RRS405)Byg/Sugt1^+ Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129P2/OlaHsd * C57BL/6J	MGI:5696984

Genotype
MGI:5696983

hm1

• Allelic Composition: Sugt1^{Gt(RRS405)Byg}/Sugt1^{Gt(RRS405)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to organogenesis ( J:226313 )

• homozygous knockout embryos at embryonic day (E) 3.5 were obtained by in vitro fertilization, whereas homozygous knockout embryos from E8.5 to E14.5 were not obtained in vivo

Genotype
MGI:5696984

cx2

• Allelic Composition: Sugt1^{Gt(RRS405)Byg}/Sugt1⁺; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

mortality/aging

increased tumor-free survival time ( J:226313 )

• significantly longer survival than of p53 knockout mice, but not as long as wild type controls

cellular

cellular phenotype ( J:226313 )

N • kinetochore formation, spindle checkpoint and ploidy are normal in MEFs

N • no significant difference in HRas-induced senescence and apoptosis between Sgt1+/ p53 MEF cells and Sgt1+/+ p53/ MEF cells