Phenotypes associated with this allele

• Allele Symbol: Zfp516^{Gt(A044B05)Wrst}
• Allele Name: gene trap A044B05, German Gene Trap Consortium
• Allele ID: MGI:4337894
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfp516^Gt(A044B05)Wrst/Zfp516^Gt(A044B05)Wrst	involves: 129S2/SvPas * C57BL/6J	MGI:6380546

Genotype
MGI:6380546

hm1

• Allelic Composition: Zfp516^{Gt(A044B05)Wrst}/Zfp516^{Gt(A044B05)Wrst}
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:218161 )

• mice die immediately after birth

adipose tissue

abnormal brown fat cell morphology ( J:218161 )

• abnormal cell morphology in the presumptive brown adipose tissue (BAT) is seen at E20.5

• mitochondria from presumptive BAT at E20.5 have randomly oriented cristae

• presumptive BAT show a near complete loss of lipid staining at E20.5

abnormal brown fat cell differentiation ( J:218161 )

• MEFs fail to differentiate into brown adipocytes in culture

decreased white fat cell size ( J:218161 )

• white adipose tissue shows decreased cell size at E20.5

cellular

abnormal brown fat cell differentiation ( J:218161 )

• MEFs fail to differentiate into brown adipocytes in culture

disorganized mitochondrial cristae ( J:218161 )

• mitochondria from presumptive BAT at E20.5 have randomly oriented cristae