Analysis Tools
mortality/aging
| N |
• normal survival
|
nervous system
|
• in the striatum at 6 months
|
|
• from 3 to 12 months
|
|
• reduced volume at 3 and 6 months
|
|
• reduced volume at 6 months
|
|
• progressive reduction in volume from 3 to 12 months
|
|
• reduced volume at 3 and 6 months
|
|
• progressive reduction in volume from 3 to 12 months
|
|
• reduced weight from 3 to 12 months
|
|
• in the striatum at 6 months
|
behavior/neurological
|
• mice exhibit impaired motor learning only on day 1 after training on a fixed speed rotarod compared with wild-type mice
|
|
• at 2 months, mice exhibit reduced climbing compared with wild-type mice
• mice exhibit impaired motor learning only on day 1 after training on a fixed speed rotarod compared with wild-type mice
• however, mice exhibit normal performance on an accelerating rotarod and motivation to climb is normal
|
|
• from 3 to 12 months
|
integument
sparse hair
(
J:191129
)
|
• hypotrichosis
|
|
• reduced density at P7
|
growth/size/body
|
• at 12 months
|
cellular
|
• in the striatum at 6 months
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Huntington's disease | DOID:12858 |
OMIM:143100 |
J:191129 | |
