Phenotypes associated with this allele

• Allele Symbol: Dyrk1a^{Gt(XQ0369)Wtsi}
• Allele Name: gene trap XQ0369, Wellcome Trust Sanger Institute
• Allele ID: MGI:4338238
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dyrk1a^Gt(XQ0369)Wtsi/Dyrk1a^Gt(XQ0369)Wtsi	involves: 129/Sv * 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	MGI:5690049
ht2	Dyrk1a^Gt(XQ0369)Wtsi/Dyrk1a^+	involves: 129/Sv * 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	MGI:5690050
cx3	Dp(16Lipi-Zbtb21)1Yey/0 Dyrk1a^Gt(XQ0369)Wtsi/Dyrk1a^+	involves: 129/Sv * 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	MGI:5690053

Genotype
MGI:5690049

hm1

• Allelic Composition: Dyrk1a^{Gt(XQ0369)Wtsi}/Dyrk1a^{Gt(XQ0369)Wtsi}
• Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:224899 )

• no viable pups are produced from heterozygote x heterozygote matings

Genotype
MGI:5690050

ht2

• Allelic Composition: Dyrk1a^{Gt(XQ0369)Wtsi}/Dyrk1a⁺
• Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

reproductive system

transmission ratio distortion ( J:224899 )

• mutation is transmitted at a ratio that is lower than expected

Genotype
MGI:5690053

cx3

• Allelic Composition: Dp(16Lipi-Zbtb21)1Yey/0; Dyrk1a^{Gt(XQ0369)Wtsi}/Dyrk1a⁺
• Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

behavior/neurological

impaired contextual conditioning behavior ( J:224899 )

• mice exhibit decreased freezing behavior in contextual fear-conditioning test as compared to wild type

decreased exploration in new environment ( J:224899 )

• impaired performance in T maze spontaneous alteration test as compared to controls