Analysis Tools
mortality/aging
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• mice are present in utero until E12.5
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cardiovascular system
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• no vascular system develops
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• at E8.0, mice lack a developed heart field
• delayed at E10.5 without heart looping and development of a multi-chambered heart structure
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• at E10.5
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• in the thoracoabdominal region at E12.5
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embryo
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• in embryos at E12.5
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• unturned at E8.0
• delayed turning by E10.5
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• at E8.5
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• at E8.0 and E10.5
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nervous system
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• at E10.5 without formation of the three primary brain vesicles
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vision/eye
cellular
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• embryonic cells accumulate premature termination codon-containing splice variant transcripts from 9% of genes predicted to contain alternative splicing events capable of eliciting nonsense-mediated mRNA decay
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• in embryos at E12.5
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• in embryos at E12.5
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growth/size/body
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• at E8.0 and E10.5
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craniofacial
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• at E8.0, mice lack an optic pit indentation
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