Phenotypes associated with this allele

• Allele Symbol: Brd2^{Gt(RRT234)Byg}
• Allele Name: gene trap RRT234, BayGenomics
• Allele ID: MGI:4340588
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Brd2^Gt(RRT234)Byg/Brd2^Gt(RRT234)Byg	B6.129P2-Brd2^Gt(RRT234)Byg	MGI:4453559
ht2	Brd2^Gt(RRT234)Byg/Brd2^+	B6.129P2-Brd2^Gt(RRT234)Byg	MGI:4453560

Genotype
MGI:4453559

hm1

• Allelic Composition: Brd2^{Gt(RRT234)Byg}/Brd2^{Gt(RRT234)Byg}
• Genetic Background: B6.129P2-Brd2^{Gt(RRT234)Byg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:159964 )

• although present in normal Mendelian ratios until E20.5, very few mice are born alive

postnatal lethality, incomplete penetrance ( J:159964 )

• very few mice survive to weaning

Genotype
MGI:4453560

ht2

• Allelic Composition: Brd2^{Gt(RRT234)Byg}/Brd2⁺
• Genetic Background: B6.129P2-Brd2^{Gt(RRT234)Byg}

homeostasis/metabolism

abnormal blood homeostasis ( J:159964 )

decreased circulating glucose level ( J:159964 )

• as early as 4 weeks

• in random and fasting samples

increased circulating glucagon level ( J:159964 )

• at 9 months of age

increased circulating insulin level ( J:159964 )

increased circulating leptin level ( J:159964 )

• at 9 months of age

abnormal circulating lipid level ( J:159964 )

• at 9 months of age, mice exhibit increased circulating lipid levels compared with wild-type mice

• however, levels of plasma non-esterified fatty acids are normal

increased circulating cholesterol level ( J:159964 )

• at 9 months of age

increased circulating triglyceride level ( J:159964 )

• at 9 months of age

increased circulating interleukin-1 beta level ( J:159964 )

• at 9 months of age

increased circulating tumor necrosis factor level ( J:159964 )

• at 9 months of age

abnormal respiratory quotient ( J:159964 )

• the respiratory exchange rate of obese mice remains at a fasting level regardless of feeding state unlike in wild-type mice

improved glucose tolerance ( J:159964 )

• prior to the onset of obesity and during chronic obesity, mice exhibit improved glucose clearance and tolerance with increased insulin secretion compared with wild-type mice

increased circulating adiponectin level ( J:159964 )

• at 9 months of age

increased basal metabolism ( J:159964 )

• whether fasted or fed, mice produce twice as much heat as wild-type mice

adipose tissue

abnormal adipose tissue morphology ( J:159964 )

• obese mice do not exhibit increased macrophage infiltration of adipose tissue unlike in obese wild-type mice fed a high fat diet

increased total body fat amount ( J:159964 )

• fat deposition is abundant and widespread with skeletal muscles encased in thick layers of fat with adipose deposits throughout unlike in wild-type mice

increased fat cell size ( J:159964 )

• the percent of large epididymal and subcutaneous adipocytes is increased compared to in wild-type mice

• however, the number of small adipocytes is normal

increased epididymal fat pad weight ( J:159964 )

• three times heavier

increased interscapular fat pad weight ( J:159964 )

• twice as much as in wild type mice and obese wild-type mice fed a high fat diet

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:159964 )

• obese mice exhibit an increase in islet size and number compared with wild-type mice

• however, islet integrity is normal

increased pancreatic beta cell number ( J:159964 )

• in young mice

increased pancreatic islet number ( J:159964 )

• in obese mice

pancreatic islet hyperplasia ( J:159964 )

• in obese mice

growth/size/body

obese ( J:159964 )

• beginning at 2 months of age when fed a regular diet

behavior/neurological

abnormal eating behavior ( J:159964 )

• at 8 weeks of age

liver/biliary system

hepatic steatosis ( J:159964 )

• in obese mice

immune system

increased circulating interleukin-1 beta level ( J:159964 )

• at 9 months of age

increased circulating tumor necrosis factor level ( J:159964 )

• at 9 months of age