Phenotypes associated with this allele

• Allele Symbol: Grhl2^{Gt(RRU622)Byg}
• Allele Name: gene trap RRU622, BayGenomics
• Allele ID: MGI:4340678
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grhl2^Gt(RRU622)Byg/Grhl2^Gt(RRU622)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:4867719

Genotype
MGI:4867719

hm1

• Allelic Composition: Grhl2^{Gt(RRU622)Byg}/Grhl2^{Gt(RRU622)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:167065 )

• embryo death around E11.5

embryo

embryonic growth retardation ( J:167065 )

• progressive developmental retardation after 22 somite stage

• development pace is normal through 22 somite stage (Theiler stage 15)

abnormal neural fold elevation formation ( J:167065 )

• neural fold elevation has not yet occurred at E9.5

• neuroepithelium remains convex

• neural plate becomes furrowed normally and median hinge point formed at E9.5

everted embryonic neuroepithelium ( J:167065 )

• neuroepithelium remains convex

incomplete caudal neuropore closure ( J:167065 )

• posterior neural tube closure fails

• axial rotation is completed

• neural closure is initiated

incomplete rostral neuropore closure ( J:167065 )

• cranial neural tube closure is not achieved

spina bifida ( J:167065 )

• anterior spina bifida

• lumbosacral spina bifida by E11.5

nervous system

everted embryonic neuroepithelium ( J:167065 )

• neuroepithelium remains convex

incomplete caudal neuropore closure ( J:167065 )

• posterior neural tube closure fails

• axial rotation is completed

• neural closure is initiated

incomplete rostral neuropore closure ( J:167065 )

• cranial neural tube closure is not achieved

spina bifida ( J:167065 )

• anterior spina bifida

• lumbosacral spina bifida by E11.5

exencephaly ( J:167065 )

limbs/digits/tail

curly tail ( J:167065 )

• irregularly curved by E11.5

craniofacial

facial cleft ( J:167065 )

• split face malformation

growth/size/body

facial cleft ( J:167065 )

• split face malformation

embryonic growth retardation ( J:167065 )

• progressive developmental retardation after 22 somite stage

• development pace is normal through 22 somite stage (Theiler stage 15)