All Phenotypes Shmt1<Gt(AD0236)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Shmt1^{Gt(AD0236)Wtsi}
gene trap AD0236, Wellcome Trust Sanger Institute
MGI:4344587

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Shmt1^{Gt(AD0236)Wtsi}/Shmt1^{Gt(AD0236)Wtsi}	B6.129P2-Shmt1^{Gt(AD0236)Wtsi}	MGI:5426848
cx2	Apc^Min/Apc⁺ Shmt1^{Gt(AD0236)Wtsi}/Shmt1^{Gt(AD0236)Wtsi}	B6.Cg-Shmt1^{Gt(AD0236)Wtsi} Apc^Min	MGI:5426849
cx3	Shmt1^{Gt(AD0236)Wtsi}/Shmt1^{Gt(AD0236)Wtsi} Tg(IGL-MYC)3Hm/0	B6.Cg-Shmt1^{Gt(AD0236)Wtsi} Tg(IGL-MYC)3Hm	MGI:5426850
cx4	Shmt1^{Gt(AD0236)Wtsi}/Shmt1^{Gt(AD0236)Wtsi} Trp53^tm1Brd/Trp53^tm1Brd	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	MGI:5426852

Allelic Composition	Shmt1^{Gt(AD0236)Wtsi}/Shmt1^{Gt(AD0236)Wtsi}
Genetic Background	B6.129P2-Shmt1^{Gt(AD0236)Wtsi}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shmt1^{Gt(AD0236)Wtsi} mutation (0 available); any Shmt1 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:183477 )

N	• mice are born at the expected Mendelian frequency

Allelic Composition	Apc^Min/Apc⁺ Shmt1^{Gt(AD0236)Wtsi}/Shmt1^{Gt(AD0236)Wtsi}
Genetic Background	B6.Cg-Shmt1^{Gt(AD0236)Wtsi} Apc^Min

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (158 available)
Shmt1^{Gt(AD0236)Wtsi} mutation (0 available); any Shmt1 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:183477 )

N	• mice exhibit the same tumorigenesis as Apc^Min heterozygotes

Allelic Composition	Shmt1^{Gt(AD0236)Wtsi}/Shmt1^{Gt(AD0236)Wtsi} Tg(IGL-MYC)3Hm/0
Genetic Background	B6.Cg-Shmt1^{Gt(AD0236)Wtsi} Tg(IGL-MYC)3Hm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shmt1^{Gt(AD0236)Wtsi} mutation (0 available); any Shmt1 mutation (43 available)
Tg(IGL-MYC)3Hm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor growth/size ( J:183477 )

• mice exhibit accelerated tumorigenesis compared with Tg(IGL-MYC)3Hm mice

Allelic Composition	Shmt1^{Gt(AD0236)Wtsi}/Shmt1^{Gt(AD0236)Wtsi} Trp53^tm1Brd/Trp53^tm1Brd
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shmt1^{Gt(AD0236)Wtsi} mutation (0 available); any Shmt1 mutation (43 available)
Trp53^tm1Brd mutation (5 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:183477 )

N	• mice exhibit the same tumorigenesis as Trp53^tm1Brd

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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