All Phenotypes Tet2<Gt(AN0709)Wtsi> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tet2^{Gt(AN0709)Wtsi}/Tet2^{Gt(AN0709)Wtsi}	B6.129P2-Tet2^{Gt(AN0709)Wtsi}	MGI:5141271
ht2	Tet2^{Gt(AN0709)Wtsi}/Tet2⁺	B6.129P2-Tet2^{Gt(AN0709)Wtsi}	MGI:5141272

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:174052 )

• some aged mice develop a lethal phenotype

hematopoietic system

abnormal monocyte differentiation ( J:174052 )

• some aged mice exhibit abnormal myelononocytic differentiation compared with wild-type mice

abnormal common myeloid progenitor cell morphology ( J:174052 )

• mice exhibit increased common myeloid progenitors (CMP) and megakaryocyte-erythrocyte progenitors (MEP) compared with control mice

• mice exhibit reduced numbers of granulocyte-macrophage progenitor cells compared with control mice

decreased pro-B cell number ( J:174052 )

• in the bone marrow

extramedullary hematopoiesis ( J:174052 )

anemia ( J:174052 )

• in some aged mice

increased erythroid progenitor cell number ( J:174052 )

• some aged mice exhibit erythroid lineage hyperplasia with abnormal myelononocytic differentiation compared with wild-type mice

decreased erythrocyte cell number ( J:174052 )

• at 4 months and in some aged mice

thrombocytopenia ( J:174052 )

• at 4 months and in some aged mice

decreased pre-B cell number ( J:174052 )

• in the bone marrow

increased leukocyte cell number ( J:174052 )

• modest at 4 months and in some aged mice

increased double-negative T cell number ( J:174052 )

• in the thymus

increased DN1 thymic pro-T cell number ( J:174052 )

• in the thymus

increased B cell number ( J:174052 )

• in the spleen

increased monocyte cell number ( J:174052 )

• mice exhibit increased myelomonocytic cells in the peripheral blood and spleen compared with control mice

increased hematopoietic stem cell number ( J:174052 )

• mice exhibit a slight increase in the absolute number of CD150+CD48- LSK cells compared with control mice

abnormal spleen morphology ( J:174052 )

• some aged mice exhibit complete spleen effacement and fibrosis unlike wild-type mice

enlarged spleen ( J:174052 )

• at 4 months and massive in some aged mice

liver/biliary system

enlarged liver ( J:174052 )

• at 4 months and massive in some aged mice

liver inflammation ( J:174052 )

• some aged mice exhibit massive perivascular and interstitial infiltration of the liver with myeloid elements unlike wild-type mice

growth/size/body

weight loss ( J:174052 )

• in some aged mice

enlarged liver ( J:174052 )

• at 4 months and massive in some aged mice

enlarged spleen ( J:174052 )

• at 4 months and massive in some aged mice

immune system

abnormal monocyte differentiation ( J:174052 )

• some aged mice exhibit abnormal myelononocytic differentiation compared with wild-type mice

decreased pro-B cell number ( J:174052 )

• in the bone marrow

decreased pre-B cell number ( J:174052 )

• in the bone marrow

increased leukocyte cell number ( J:174052 )

• modest at 4 months and in some aged mice

increased double-negative T cell number ( J:174052 )

• in the thymus

increased DN1 thymic pro-T cell number ( J:174052 )

• in the thymus

increased B cell number ( J:174052 )

• in the spleen

increased monocyte cell number ( J:174052 )

• mice exhibit increased myelomonocytic cells in the peripheral blood and spleen compared with control mice

abnormal spleen morphology ( J:174052 )

• some aged mice exhibit complete spleen effacement and fibrosis unlike wild-type mice

enlarged spleen ( J:174052 )

• at 4 months and massive in some aged mice

liver inflammation ( J:174052 )

• some aged mice exhibit massive perivascular and interstitial infiltration of the liver with myeloid elements unlike wild-type mice

cellular

abnormal monocyte differentiation ( J:174052 )

• some aged mice exhibit abnormal myelononocytic differentiation compared with wild-type mice

endocrine/exocrine glands

increased DN1 thymic pro-T cell number ( J:174052 )

• in the thymus

Allelic Composition	Tet2^{Gt(AN0709)Wtsi}/Tet2⁺
Genetic Background	B6.129P2-Tet2^{Gt(AN0709)Wtsi}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tet2^{Gt(AN0709)Wtsi} mutation (0 available); any Tet2 mutation (779 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:174052 )

• some aged mice develop a lethal phenotype

hematopoietic system

abnormal monocyte differentiation ( J:174052 )

• some aged mice exhibit abnormal myelononocytic differentiation compared with wild-type mice

anemia ( J:174052 )

• in some aged mice

increased erythroid progenitor cell number ( J:174052 )

• some aged mice exhibit erythroid lineage hyperplasia with abnormal myelononocytic differentiation compared with wild-type mice

decreased erythrocyte cell number ( J:174052 )

• in some aged mice

thrombocytopenia ( J:174052 )

• in some aged mice

increased leukocyte cell number ( J:174052 )

• in some aged mice

increased B cell number ( J:174052 )

increased monocyte cell number ( J:174052 )

• mice exhibit increased myelomonocytic cells compared with control mice

abnormal spleen morphology ( J:174052 )

• some aged mice exhibit complete spleen effacement and fibrosis unlike wild-type mice

enlarged spleen ( J:174052 )

• massive in some aged mice

liver/biliary system

enlarged liver ( J:174052 )

• massive in some aged mice

liver inflammation ( J:174052 )

• some aged mice exhibit massive perivascular and interstitial infiltration of the liver with myeloid elements unlike wild-type mice

liver fibrosis ( J:174052 )

• moderate in some aged mice

growth/size/body

weight loss ( J:174052 )

• in some aged mice

enlarged liver ( J:174052 )

• massive in some aged mice

enlarged spleen ( J:174052 )

• massive in some aged mice

immune system

abnormal monocyte differentiation ( J:174052 )

• some aged mice exhibit abnormal myelononocytic differentiation compared with wild-type mice

increased leukocyte cell number ( J:174052 )

• in some aged mice

increased B cell number ( J:174052 )

increased monocyte cell number ( J:174052 )

• mice exhibit increased myelomonocytic cells compared with control mice

abnormal spleen morphology ( J:174052 )

• some aged mice exhibit complete spleen effacement and fibrosis unlike wild-type mice

enlarged spleen ( J:174052 )

• massive in some aged mice

liver inflammation ( J:174052 )

• some aged mice exhibit massive perivascular and interstitial infiltration of the liver with myeloid elements unlike wild-type mice

cellular

abnormal monocyte differentiation ( J:174052 )

• some aged mice exhibit abnormal myelononocytic differentiation compared with wild-type mice

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