Phenotypes associated with this allele

• Allele Symbol: Prkab2^{Gt(AL0483)Wtsi}
• Allele Name: gene trap AL0483, Wellcome Trust Sanger Institute
• Allele ID: MGI:4345788
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prkab2^Gt(AL0483)Wtsi/Prkab2^Gt(AL0483)Wtsi	B6.129P2-Prkab2^Gt(AL0483)Wtsi	MGI:5433120

Genotype
MGI:5433120

hm1

• Allelic Composition: Prkab2^{Gt(AL0483)Wtsi}/Prkab2^{Gt(AL0483)Wtsi}
• Genetic Background: B6.129P2-Prkab2^{Gt(AL0483)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

impaired exercise endurance ( J:186658 )

decreased circulating glucose level ( J:186658 )

• after a 48 hr of fasting

• in mice fed a high fat diet

increased circulating insulin level ( J:186658 )

• in mice fed a high fat diet

increased circulating triglyceride level ( J:186658 )

• double in mice fed a high fat diet

impaired glucose tolerance ( J:186658 )

• in mice fed a high fat diet

decreased glycogen catabolism rate ( J:186658 )

• fasted or exercise mice fail to break down glycogen

decreased skeletal muscle glycogen level ( J:186658 )

• after a 48 hr of fasting

• in mice fed a high fat diet

insulin resistance ( J:186658 )

• in mice fed a high fat diet

adipose tissue

increased total body fat amount ( J:186658 )

• 4 to 5 times in mice fed a high fat diet

muscle

decreased muscle cell glucose uptake ( J:186658 )

• mice fed standard chow exhibit impaired AICAR- and insulin-stimulated glucose uptake compared with wild-type mice

• mice fed a high fat diet exhibit impaired insulin-stimulated glucose uptake compared with wild-type mice

decreased skeletal muscle glycogen level ( J:186658 )

• after a 48 hr of fasting

• in mice fed a high fat diet

behavior/neurological

impaired exercise endurance ( J:186658 )

cellular

decreased muscle cell glucose uptake ( J:186658 )

• mice fed standard chow exhibit impaired AICAR- and insulin-stimulated glucose uptake compared with wild-type mice

• mice fed a high fat diet exhibit impaired insulin-stimulated glucose uptake compared with wild-type mice