Analysis Tools|
Allele Symbol Allele Name Allele ID |
Cers2Gt(S16-4B1)Sor gene trap S16-4B1, Philippe Soriano MGI:4346044 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Abnormal morphology of Cers2Gt(S16-4B1)Sor/Cers2Gt(S16-4B1)Sor trigeminal nerve axons
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• at 9 months, multiple empty cysts are found in the white matter unlike in wild-type mice
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• smaller than in wild-type mice with ragged contours
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• at 9 months, multiple empty cysts are found in the internal granular layer unlike in wild-type mice
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• 20% of axons in the trigeminal nerve exhibit inner surface defects of the myelin sheaths, including vesiculation and multifocal detachment of the inner myelin lamella, unlike in wild-type mice
• myelin stainability is progressively lost
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• 20% of axons in the trigeminal nerve exhibit inner surface defects of the myelin sheaths, including vesiculation and multifocal detachment of the inner myelin lamella, unlike in wild-type mice
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• 1 mouse developed multiple liver adenomata
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• tumor cells are pale hepatocytes often filled with large lipid droplets
• between 7 and 9 months, 2 of 3 mice develop hepatocellular carcinoma
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• fewer very long fatty acid ceramide species are detected in the brain, liver, and kidneys compared to in wild-type mice
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• 1 mouse developed multiple liver adenomata
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• between 7 and 9 months, 2 of 3 mice develop hepatocellular carcinoma
• tumor cells are pale hepatocytes often filled with large lipid droplets
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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