Phenotypes associated with this allele

• Allele Symbol: Fuz^{Gt(AN0439)Wtsi}
• Allele Name: gene trap AN0439, Wellcome Trust Sanger Institute
• Allele ID: MGI:4346364
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fuz^Gt(AN0439)Wtsi/Fuz^Gt(AN0439)Wtsi	involves: 129P2/OlaHsd * C3H	MGI:4412414

Genotype
MGI:4412414

hm1

• Allelic Composition: Fuz^{Gt(AN0439)Wtsi}/Fuz^{Gt(AN0439)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C3H

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:154370 )

• do not recover any live embryos after E14.5

embryo

abnormal developmental patterning ( J:154370 )

• at E10.5 some mice display a twisted body axis

abnormal apical ectodermal ridge morphology ( J:154370 )

• expression analysis indicates abnormal anterior posterior patterning of the apical ectodermal ridge at E10.5

small floor plate ( J:154370 )

• expression analysis indicates a large reduction in the size of the floor plate at E10.5

abnormal neural tube closure ( J:154370 )

• defects in neural tube closure are detected at E10.5

limbs/digits/tail

abnormal apical ectodermal ridge morphology ( J:154370 )

• expression analysis indicates abnormal anterior posterior patterning of the apical ectodermal ridge at E10.5

polydactyly ( J:154370 )

• at E12.5 all display severe polydactyly with 7-9 digits on the forelimbs and 6-8 on the hindlimbs

homeostasis/metabolism

edema ( J:154370 )

• widespread edema at E14.5

pericardial edema ( J:154370 )

• mild edema is seen in some mice at E10.5

nervous system

small floor plate ( J:154370 )

• expression analysis indicates a large reduction in the size of the floor plate at E10.5

abnormal neural tube closure ( J:154370 )

• defects in neural tube closure are detected at E10.5

abnormal midbrain morphology ( J:154370 )

• a tight mesencephalic flexure is detected at E10.5

abnormal spinal cord morphology ( J:154370 )

• abnormal dorsal ventral patterning at E10.5

abnormal motor neuron morphology ( J:154370 )

• at E10.5 motor neurons are expanded into the ventral midline of the developing spinal cord

abnormal ventral interneuron 3 morphology ( J:154370 )

• at E10.5, V3 interneurons and their progenitors are located in the ventral midline

vision/eye

absent eye pigmentation ( J:154370 )

• at E12.5 and E14.5

microphthalmia ( J:154370 )

• at E12.5

cellular

abnormal primary cilium morphology ( J:154370 )

• at E11.5 fewer primary cilia are detected on most cells including spinal cord cells, mesenchymal cells surrounding the notochord and mesenchymal cells in the limb buds

pigmentation

absent eye pigmentation ( J:154370 )

• at E12.5 and E14.5

cardiovascular system

pericardial edema ( J:154370 )

• mild edema is seen in some mice at E10.5