Phenotypes associated with this allele

• Allele Symbol: Il2^m1
• Allele Name: mutation 1
• Allele ID: MGI:4352594
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il2^m1/Il2^m1	MRL/MpJ	MGI:4352597

Genotype
MGI:4352597

hm1

• Allelic Composition: Il2^m1/Il2^m1
• Genetic Background: MRL/MpJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T cell activation ( J:75331 )

• splenocytes stimulated with concanavalin A for 2 days in culture have lower induction of T cell activation markers including CD25 and lower secretion of IL2, lower than normal levels of activation induced cell death by CD3 or FASL crosslinking, and addition of recombinant IL2, derived from the FVB/NJ coding sequence, with concanavalin A to MRL/MpJ splenocytes in culture partially or fully restores activation markers and restores normal activation induced cell death

immune system

abnormal T cell activation ( J:75331 )

• splenocytes stimulated with concanavalin A for 2 days in culture have lower induction of T cell activation markers including CD25 and lower secretion of IL2, lower than normal levels of activation induced cell death by CD3 or FASL crosslinking, and addition of recombinant IL2, derived from the FVB/NJ coding sequence, with concanavalin A to MRL/MpJ splenocytes in culture partially or fully restores activation markers and restores normal activation induced cell death