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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Smad7-cre)1Sjc
transgene insertion 1, Simon J Conway
MGI:4352679
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
Tg(Smad7-cre)1Sjc/0
involves: 129S/Sv * C3HeB/FeJ MGI:4352743


Genotype
MGI:4352743
cn1
Allelic
Composition
Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
Tg(Smad7-cre)1Sjc/0
Genetic
Background
involves: 129S/Sv * C3HeB/FeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Jpmb mutation (2 available); any Gt(ROSA)26Sor mutation (992 available)
Tg(Smad7-cre)1Sjc mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Cardiovascular abnormalities in Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+ Tg(Smad7-cre)1Sjc/0 embryos

mortality/aging
• cardiovascular developmental abnormalities result in in utero death

embryo
• yolk sacs of mutant embryos have almost no vasculature compared to controls
• observed in E10.5 embryos

cardiovascular system
N
• in mutants, ventricular myocardium and endothelial layer are intact
• vessels are weakened and hemorrhagic in embryos
• dorsal aorta is fragmented and contains only a few smooth muscle cells
• yolk sacs of mutant embryos have almost no vasculature compared to controls
• atrioventricular (AV) cushion region is largely absent in mutants
• cushion hypoplasia is observed at E10
• E10.5 embryos have smaller hearts relative to controls
• E10.5 embryos are hemorrhagic

craniofacial
• observed in E10.5 embryos





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory