mortality/aging
• cardiovascular developmental abnormalities result in in utero death
|
embryo
• yolk sacs of mutant embryos have almost no vasculature compared to controls
|
• observed in E10.5 embryos
|
cardiovascular system
N |
• in mutants, ventricular myocardium and endothelial layer are intact
|
• vessels are weakened and hemorrhagic in embryos
|
• dorsal aorta is fragmented and contains only a few smooth muscle cells
|
• yolk sacs of mutant embryos have almost no vasculature compared to controls
|
• atrioventricular (AV) cushion region is largely absent in mutants
|
• cushion hypoplasia is observed at E10
|
small heart
(
J:150864
)
• E10.5 embryos have smaller hearts relative to controls
|
hemorrhage
(
J:150864
)
• E10.5 embryos are hemorrhagic
|
craniofacial
• observed in E10.5 embryos
|