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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Myctm4.1Fwa
targeted mutation 4.1, Frederick W Alt
MGI:4352684
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Myctm4.1Fwa/Myctm4.1Fwa involves: 129S6/SvEvTac MGI:4352687


Genotype
MGI:4352687
hm1
Allelic
Composition		 Myctm4.1Fwa/Myctm4.1Fwa
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myctm4.1Fwa mutation (0 available); any Myc mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
induced chromosome breakage ( J:150339 )
• infection of B cells with a ISceI-expressing retrovirus leads to chromosome breakage at the Myc allele in about 10% of the cells
• activating these B cells leads to Igh-Myc translocations that occur at a rate 100-fold greater than controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory