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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Calcrtm1Rda
targeted mutation 1, Rachel A Davey
MGI:4352932
Summary 2 genotypes


Genotype
MGI:4353057
cn1
Allelic
Composition		 Calcrtm1Rda/Calcrtm1Rda
Tg(Acp5-cre)4Rda/0
Genetic
Background		 B6.Cg-Calcrtm1Rda Tg(Acp5-cre)4Rda
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Calcrtm1Rda mutation (2 available); any Calcr mutation (59 available)
Tg(Acp5-cre)4Rda mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:150982 )
• no pups with this genotype are born alive




Genotype
MGI:4353058
cn2
Allelic
Composition		 Calcrtm1Rda/Calcrtm1Rda
Tg(CMV-cre)1Cgn/0
Genetic
Background		 B6.Cg-Calcrtm1Rda Tg(CMV-cre)1Cgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Calcrtm1Rda mutation (2 available); any Calcr mutation (59 available)
Tg(CMV-cre)1Cgn mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal circulating hormone level ( J:150982 )
• levels are increased to 40 and 34 pg/ml in male and female mice from basal levels of less than 5 pg/ml in controls
abnormal circulating calcium level ( J:150982 )
• mice have higher rises in serum calcium level when administered calcitrol (active form of vitamin D) than controls
• rise in serum calcium is 44% higher in males and 21% higher in females

immune system
abnormal osteoclast physiology ( J:150982 )
• bone marrow derived osteoclasts fail to dissemble actin rings in response to calcitonin

limbs/digits/tail
short femur ( J:150982 )
• femur length in male mice is 4% shorter than controls at 6, 12, and 24 weeks of age

skeleton
abnormal osteoclast physiology ( J:150982 )
• bone marrow derived osteoclasts fail to dissemble actin rings in response to calcitonin
short femur ( J:150982 )
• femur length in male mice is 4% shorter than controls at 6, 12, and 24 weeks of age
abnormal bone trabecula morphology ( J:150982 )
• the trabecular structures in female mice are more rod-like than plate-like
• trabecular separation in the vertebrae of male mice is increased compared to controls
increased trabecular bone mass ( J:150982 )
• trabecular bone formation is increased 20-40% in the femur of male mice
abnormal trabecular bone thickness ( J:150982 )
• trabecular bone volume in vertebrae of female mice is reduced by 6% at 6 weeks of age
• however, female mice do not have vertebrae trabecular bone loss as the age as controls do leading to 27% increase in bone volume by 24 weeks of age
• also, connectivity density is doubled in trabecular bone
• in female femur, trabecular thickness is decreased by 11% compared to controls

hematopoietic system
abnormal osteoclast physiology ( J:150982 )
• bone marrow derived osteoclasts fail to dissemble actin rings in response to calcitonin




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory