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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Antxr2tm1.2Lepp
targeted mutation 1.2, Stephen H Leppla
MGI:4352944
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Antxr2tm1.2Lepp/Antxr2tm1.2Lepp involves: C57BL/6 MGI:4352948
cx2
 		Antxr1tm1.2Lepp/Antxr1tm1.2Lepp
Antxr2tm1.2Lepp/Antxr2tm1.2Lepp 		involves: 129 * C57BL/6 MGI:4352950


Genotype
MGI:4352948
hm1
Allelic
Composition		 Antxr2tm1.2Lepp/Antxr2tm1.2Lepp
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Antxr2tm1.2Lepp mutation (0 available); any Antxr2 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to bacterial infection induced morbidity/mortality ( J:150952 )
• mice are completely resistant to anthrax lethal toxin and edema toxin induced lethality when given a single dose of the toxin
• when given multiple doses (100 ug each)of anthrax lethal toxin all mice survive 2 doses, 70% survive 3 doses and 30% survive 5 doses
• mice are highly resistant to Bacillus anthracis Ames strain (A35) induced lethality with only 1 of 11 mice succumbing at a very late time point following infection with a dose that is highly lethal to wild-type mice

cellular
decreased sensitivity to induced cell death ( J:150952 )
• the concentration of anthrax toxin protective antigen required to kill 50% of MEF cells in the presence of FP59 is increased to 12 ng/ml compared to 1.8 ng/ml for wild-type cells

immune system
decreased susceptibility to bacterial infection induced morbidity/mortality ( J:150952 )
• mice are completely resistant to anthrax lethal toxin and edema toxin induced lethality when given a single dose of the toxin
• when given multiple doses (100 ug each)of anthrax lethal toxin all mice survive 2 doses, 70% survive 3 doses and 30% survive 5 doses
• mice are highly resistant to Bacillus anthracis Ames strain (A35) induced lethality with only 1 of 11 mice succumbing at a very late time point following infection with a dose that is highly lethal to wild-type mice

reproductive system
female infertility ( J:150952 )
• females but not males are infertile
• females become pregnant but fail to support normal embryonic development




Genotype
MGI:4352950
cx2
Allelic
Composition		 Antxr1tm1.2Lepp/Antxr1tm1.2Lepp
Antxr2tm1.2Lepp/Antxr2tm1.2Lepp
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Antxr1tm1.2Lepp mutation (1 available); any Antxr1 mutation (30 available)
Antxr2tm1.2Lepp mutation (0 available); any Antxr2 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to induced morbidity/mortality ( J:150952 )
• mice are completely resistant to up to 5 doses (100 ug each) of anthrax lethal toxin

cellular
decreased sensitivity to induced cell death ( J:150952 )
• MEFs are completely resistant to anthrax toxin protective antigen plus FP59 induced cell death unlike wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory