All Phenotypes Tg(Pomc-FLP)1aBrn MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Pomc-FLP)1aBrn
transgene insertion 1a, Anton Berns
MGI:4353096

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rb1^tm1Brn/Rb1^tm1Brn Tg(Pomc-FLP)1aBrn/0	involves: 129P2/OlaHsd * FVB/N	MGI:4353102
cn2	Rb1^tm1Brn/Rb1⁺ Tg(Pomc-FLP)1aBrn/0	involves: 129P2/OlaHsd * FVB/N	MGI:4353103
tg3	Tg(Pomc-FLP)1aBrn/0	involves: FVB/N	MGI:4353100

Allelic Composition	Rb1^tm1Brn/Rb1^tm1Brn Tg(Pomc-FLP)1aBrn/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1^tm1Brn mutation (1 available); any Rb1 mutation (111 available)
Tg(Pomc-FLP)1aBrn mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:48860 )

• all mice die within 20 weeks (or 5 months)

neoplasm

increased pituitary adenoma incidence ( J:48860 )

• at 12 weeks, mice develop pituitary adenomas to which they succumb within 20 weeks of age

• the average latency of tumors is 4 months and all mice die within 5 months

• tumors exhibit hyperproliferation and apoptosis is reduced in end-stage tumors

endocrine/exocrine glands

increased pituitary adenoma incidence ( J:48860 )

• at 12 weeks, mice develop pituitary adenomas to which they succumb within 20 weeks of age

• the average latency of tumors is 4 months and all mice die within 5 months

• tumors exhibit hyperproliferation and apoptosis is reduced in end-stage tumors

nervous system

increased pituitary adenoma incidence ( J:48860 )

• at 12 weeks, mice develop pituitary adenomas to which they succumb within 20 weeks of age

• the average latency of tumors is 4 months and all mice die within 5 months

• tumors exhibit hyperproliferation and apoptosis is reduced in end-stage tumors

Allelic Composition	Rb1^tm1Brn/Rb1⁺ Tg(Pomc-FLP)1aBrn/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1^tm1Brn mutation (1 available); any Rb1 mutation (111 available)
Tg(Pomc-FLP)1aBrn mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal pituitary intermediate lobe morphology ( J:48860 )

• at 6 and 12 weeks, mice exhibit atypical lesions in the intermediate lobe of the pituitary gland unlike in Rb1^tm1Brn homozygotes

increased pituitary adenoma incidence ( J:48860 )

• mice develop pituitary adenomas with an average latency of 9 months

• tumors exhibit hyperproliferation

neoplasm

increased pituitary adenoma incidence ( J:48860 )

• mice develop pituitary adenomas with an average latency of 9 months

• tumors exhibit hyperproliferation

endocrine/exocrine glands

abnormal pituitary intermediate lobe morphology ( J:48860 )

• at 6 and 12 weeks, mice exhibit atypical lesions in the intermediate lobe of the pituitary gland unlike in Rb1^tm1Brn homozygotes

increased pituitary adenoma incidence ( J:48860 )

• mice develop pituitary adenomas with an average latency of 9 months

• tumors exhibit hyperproliferation

Allelic Composition	Tg(Pomc-FLP)1aBrn/0
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:48860 )

• mice are healthy, fertile, and show no sign of disease

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