All Phenotypes Tg(Pomc-FLP)1bBrn MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rb1^tm1Brn/Rb1^tm1Brn X/Tg(Pomc-FLP)1bBrn	involves: 129P2/OlaHsd * FVB/N	MGI:4353104
cn2	Rb1^tm1Brn/Rb1⁺ X/Tg(Pomc-FLP)1bBrn	involves: 129P2/OlaHsd * FVB/N	MGI:4353105
tg3	X/Tg(Pomc-FLP)1bBrn	involves: FVB/N	MGI:4353101

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:48860 )

• mice die of tumors within 11 months

nervous system

pituitary intermediate lobe hyperplasia ( J:48860 )

• at 6 and 12 weeks, mice exhibit extensive hyperplasia with areas of more densely packed cells with nodular appearance unlike in wild-type mice

• at 12 weeks, the cell mass of the intermediate lobe is increased with a 2.5-fold higher cell density of hyperplastic areas and nodules compared to in wild-type mice

increased pituitary adenoma incidence ( J:48860 )

• mice develop pituitary adenomas at a slower rate than in Rb1^tm1Brn/ Rb1^tm1Brn Tg(Pomc-Flp)1aBrn mice with an average latency of 7 months

• tumors exhibit hyperproliferation

neoplasm

increased pituitary adenoma incidence ( J:48860 )

• mice develop pituitary adenomas at a slower rate than in Rb1^tm1Brn/ Rb1^tm1Brn Tg(Pomc-Flp)1aBrn mice with an average latency of 7 months

• tumors exhibit hyperproliferation

endocrine/exocrine glands

pituitary intermediate lobe hyperplasia ( J:48860 )

• at 6 and 12 weeks, mice exhibit extensive hyperplasia with areas of more densely packed cells with nodular appearance unlike in wild-type mice

• at 12 weeks, the cell mass of the intermediate lobe is increased with a 2.5-fold higher cell density of hyperplastic areas and nodules compared to in wild-type mice

increased pituitary adenoma incidence ( J:48860 )

• mice develop pituitary adenomas at a slower rate than in Rb1^tm1Brn/ Rb1^tm1Brn Tg(Pomc-Flp)1aBrn mice with an average latency of 7 months

• tumors exhibit hyperproliferation

Allelic Composition	Rb1^tm1Brn/Rb1⁺ X/Tg(Pomc-FLP)1bBrn
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1^tm1Brn mutation (1 available); any Rb1 mutation (111 available)
Tg(Pomc-FLP)1bBrn mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

pituitary intermediate lobe hyperplasia ( J:48860 )

• at 12 weeks in some mice

nervous system

pituitary intermediate lobe hyperplasia ( J:48860 )

• at 12 weeks in some mice

Allelic Composition	X/Tg(Pomc-FLP)1bBrn
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:48860 )

• mice are healthy, fertile, and show no sign of disease

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