Phenotypes associated with this allele

• Allele Symbol: Senp1^tm1.1Wami
• Allele Name: targeted mutation 1.1, Wang Min
• Allele ID: MGI:4353110
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Senp1^tm1.1Wami/Senp1^tm1.1Wami	involves: 129 * C57BL/6	MGI:4353117

Genotype
MGI:4353117

hm1

• Allelic Composition: Senp1^tm1.1Wami/Senp1^tm1.1Wami
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Erythropoietic defects in fetal liver of Senp1^tm1.1Wami/Senp1^tm1.1Wami mice

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:163428 )

• die between E13.5 and birth

postnatal lethality, complete penetrance ( J:163428 )

• only 3 homozygotes (out of 348 born pups) survived to 2 weeks of age and none survived past weaning

prenatal lethality, complete penetrance ( J:150995 )

hematopoietic system

abnormal granulocyte differentiation ( J:163428 )

• decrease in CFU-G numbers in samples from E13.5 fetal liver

abnormal monocyte differentiation ( J:163428 )

• increase in CFU-M numbers in samples from E13.5 fetal liver

abnormal erythropoiesis ( J:163428 )

• at E11 fetal liver sections contain fewer erythroblasts and increased abundance of immature erythroblasts

• in transplant studies cells from the fetal liver are impaired in the ability to generate erythroid cells

anemia ( J:163428 )

• in all embryos at E13.5

• all 3 live born pups had severe anemia

decreased erythroid progenitor cell number ( J:163428 )

• about a 40% decrease in CFU-E numbers in samples from E13.5 fetal liver

abnormal megakaryocyte progenitor cell morphology ( J:163428 )

• decrease in CFU-MK numbers in samples from E13.5 fetal liver

abnormal hemoglobin content ( J:163428 )

• at E13.5 fetal livers have lower levels of adult forms of hemoglobin and increased levels of embryonic forms of hemoglobin

embryo

abnormal vitelline vasculature morphology ( J:163428 )

• poor blood vessel development at E13.5

cardiovascular system

abnormal vascular development ( J:163428 )

• poor blood vessel development at E13.5

abnormal vitelline vasculature morphology ( J:163428 )

• poor blood vessel development at E13.5

liver/biliary system

small liver ( J:163428 )

• at E11.5 and E13.5

decreased liver weight ( J:163428 )

• at E11.5

pale liver ( J:163428 )

• at E13.5

abnormal liver physiology ( J:163428 )

• at E13.5 fetal livers have lower levels of adult forms of hemoglobin and increased levels of embryonic forms of hemoglobin

immune system

abnormal granulocyte differentiation ( J:163428 )

• decrease in CFU-G numbers in samples from E13.5 fetal liver

abnormal monocyte differentiation ( J:163428 )

• increase in CFU-M numbers in samples from E13.5 fetal liver

cellular

abnormal granulocyte differentiation ( J:163428 )

• decrease in CFU-G numbers in samples from E13.5 fetal liver

abnormal monocyte differentiation ( J:163428 )

• increase in CFU-M numbers in samples from E13.5 fetal liver