Phenotypes associated with this allele

• Allele Symbol: Pax7^tm1.1Fan
• Allele Name: targeted mutation 1.1, Chen-Ming Fan
• Allele ID: MGI:4353118
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^+ Pax7^tm1.1Fan/Pax7^tm2.1(cre/ERT2)Fan	involves: 129 * C57BL/6 * SJL	MGI:4353176

Genotype
MGI:4353176

cn1

• Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺; Pax7^tm1.1Fan/Pax7^{tm2.1(cre/ERT2)Fan}
• Genetic Background: involves: 129 * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

muscle phenotype ( J:150962 )

N • following tamoxifen-treatment, injury-induced myogenesis and satellite cell characteristics are normal

abnormal myogenesis ( J:150962 )

• in culture, tamoxifen-treated P0 myoblasts exhibit defective expansive and myogenic potentials compared with control Pax7^{tm2.1(cre/ERT2)Fan} heterozygous myoblasts

• however, myoblasts from tamoxifen-treated adults exhibit normal expansive and myogenic potentials

abnormal muscle regeneration ( J:150962 )

• following tamoxifen treatment between P7 and P11, regeneration is severely compromised compared to in control Pax7^{tm2.1(cre/ERT2)Fan} heterozygotes

• however, following tamoxifen treatment between P14 to P18 and P21 to P25 regeneration capacity gradually increased to levels in control Pax7^{tm2.1(cre/ERT2)Fan} heterozygotes

• following tamoxifen treatment, myofibers continue to be incorporated into a regenerating muscle beyond P31 longer than in control Pax7^{tm2.1(cre/ERT2)Fan} heterozygotes