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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pax7tm1.2Fan
targeted mutation 1.2, Chen-Ming Fan
MGI:4353152
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pax7tm1.2Fan/Pax7tm1.2Fan involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:4353175
cn2
 		Pax3tm1.1Sjc/Pax3tm1.1Sjc
Pax7tm1.2Fan/Pax7tm1.2Fan
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129 * C57BL/6 * CBA * SJL MGI:4353177


Genotype
MGI:4353175
hm1
Allelic
Composition		 Pax7tm1.2Fan/Pax7tm1.2Fan
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax7tm1.2Fan mutation (0 available); any Pax7 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
impaired skeletal muscle regeneration ( J:150962 )
• mice exhibit severe muscle regeneration defect with few regenerating myofibers and accumulation of fibrosis unlike in wild-type mice
• the few regenerating myofibers express Pax7




Genotype
MGI:4353177
cn2
Allelic
Composition		 Pax3tm1.1Sjc/Pax3tm1.1Sjc
Pax7tm1.2Fan/Pax7tm1.2Fan
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129 * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax3tm1.1Sjc mutation (0 available); any Pax3 mutation (50 available)
Pax7tm1.2Fan mutation (0 available); any Pax7 mutation (38 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
muscle phenotype ( J:150962 )
N
• following tamoxifen-treatment, muscle regeneration is normal as are the proliferative and myogenic properties of adult myoblasts




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory