Phenotypes associated with this allele

• Allele Symbol: Cux2^{Gt(OST440231)Lex}
• Allele Name: gene trap OST440231, Lexicon Genetics
• Allele ID: MGI:4353153
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cux2^Gt(OST440231)Lex/Cux2^Gt(OST440231)Lex	involves: 129S5/SvEvBrd	MGI:4353225

Genotype
MGI:4353225

hm1

• Allelic Composition: Cux2^{Gt(OST440231)Lex}/Cux2^{Gt(OST440231)Lex}
• Genetic Background: involves: 129S5/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:131816 )

• homozygous pups are produced at less than expected frequency

nervous system

abnormal neural tube morphology ( J:131816 )

• hypoplastic at E11.5

• area of tube reduced 27.8%

abnormal neural tube marginal layer morphology ( J:131816 , J:150348 )

• marginal zone is reduced (J:131816)

• reduced axonal mass in the marginal zone (J:131816)

• hypoplastic at E11.5 (J:150348)

abnormal neural tube ventricular layer morphology ( J:150348 )

• hypoplastic at E11.5

abnormal spinal cord interneuron morphology ( J:150348 )

• 40-60% reduction of various interneuron types

• reduced commissural interneurons

• reduced axonal projections from interneurons

abnormal ventral spinal root morphology ( J:150348 )

• abnormal ventral root formation

cellular

abnormal cell cycle ( J:131816 )

• 62% increase in the length of time neural progenitors spend in S phase

• slower cell cycle

decreased cell proliferation ( J:131816 )

• proliferation level normal at E10.5

• reduced neural progenitor cell proliferation at E11.5

embryo

abnormal neural tube morphology ( J:131816 )

• hypoplastic at E11.5

• area of tube reduced 27.8%

abnormal neural tube marginal layer morphology ( J:131816 , J:150348 )

• marginal zone is reduced (J:131816)

• reduced axonal mass in the marginal zone (J:131816)

• hypoplastic at E11.5 (J:150348)

abnormal neural tube ventricular layer morphology ( J:150348 )

• hypoplastic at E11.5