All Phenotypes Pax7<tm2.1(cre/ERT2)Fan> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pax7^{tm2.1(cre/ERT2)Fan}
targeted mutation 2.1, Chen-Ming Fan
MGI:4353154

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pax7^tm1.1Thbr/Pax7^{tm2.1(cre/ERT2)Fan}	involves: 129S1/Sv * 129X1/SvJ	MGI:5548071
cn2	Mamstr^tm1.1Eno/Mamstr^tm1.1Eno Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺	involves: 129 * C57BL/6	MGI:5313414
cn3	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Pax7^tm1.1Fan/Pax7^{tm2.1(cre/ERT2)Fan}	involves: 129 * C57BL/6 * SJL	MGI:4353176
cn4	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Kdm6a^tm1.1Kaig/Y Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5779969
cn5	Kdm6a^tm1.1Kaig/Kdm6a^tm1.1Kaig Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5779968
cn6	Kdm6a^tm1.1Kaig/Y Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5779970
cn7	Ar^tm2Ska/Ar^tm2Ska Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrl	MGI:7647262
cn8	Kras^tm4Tyj/Kras⁺ Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺ Trp53^tm1Brn/Trp53^tm1Brn	involves: 129/Sv * 129P2/OlaHsd * 129X1/SvJ * C57BL/6	MGI:5547938

Allelic Composition	Pax7^tm1.1Thbr/Pax7^{tm2.1(cre/ERT2)Fan}
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax7^tm1.1Thbr mutation (0 available); any Pax7 mutation (38 available)
Pax7^{tm2.1(cre/ERT2)Fan} mutation (1 available); any Pax7 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

muscle phenotype ( J:202693 )

N	• tamoxifen-treated mice do not exhibit centrally localized nuclei or differences in fiber diameter

abnormal skeletal muscle satellite cell proliferation ( J:202693 )

• reduced in tamoxifen-treated cultures

abnormal skeletal muscle morphology ( J:202693 )

• adult mice treated with tamoxifen exhibit rare atypical satellite cells with reduced heterochromatin condensation compared with control mice

decreased skeletal muscle size ( J:202693 )

• in a model of muscle regeneration, tamoxifen- and cardiotoxin-treated mice exhibit reduced total muscle size compared with control mice

decreased satellite cell number ( J:202693 )

• after tamoxifen treatment

• after tamoxifen- and cardiotoxin-treatment

skeletal muscle fibrosis ( J:202693 )

• in a model of muscle regeneration, tamoxifen- and cardiotoxin-treated mice exhibit massive increase in necrotic fibers and fibrotic tissue compared with control mice

skeletal muscle necrosis ( J:202693 )

• in a model of muscle regeneration, tamoxifen- and cardiotoxin-treated mice exhibit massive increase in necrotic fibers and fibrotic tissue compared with control mice

abnormal muscle regeneration ( J:202693 )

• in a model of muscle regeneration, tamoxifen- and cardiotoxin-treated mice exhibit reduced total muscle size and myofiber diameters with massive increase in necrotic fibers and fibrotic tissue compared with control mice

cellular

abnormal skeletal muscle satellite cell proliferation ( J:202693 )

• reduced in tamoxifen-treated cultures

Allelic Composition	Mamstr^tm1.1Eno/Mamstr^tm1.1Eno Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mamstr^tm1.1Eno mutation (0 available); any Mamstr mutation (21 available)
Pax7^{tm2.1(cre/ERT2)Fan} mutation (1 available); any Pax7 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

impaired skeletal muscle regeneration ( J:179880 )

• in tamoxifen treated mice at 3 and 7 days after cardiotoxin induced muscle damage mice show a significant decrease in the number of regenerating myofibers and persistence of necrotic fibers

Allelic Composition	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Pax7^tm1.1Fan/Pax7^{tm2.1(cre/ERT2)Fan}
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (1006 available)
Pax7^tm1.1Fan mutation (1 available); any Pax7 mutation (38 available)
Pax7^{tm2.1(cre/ERT2)Fan} mutation (1 available); any Pax7 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

muscle phenotype ( J:150962 )

N	• following tamoxifen-treatment, injury-induced myogenesis and satellite cell characteristics are normal

abnormal myogenesis ( J:150962 )

• in culture, tamoxifen-treated P0 myoblasts exhibit defective expansive and myogenic potentials compared with control Pax7^{tm2.1(cre/ERT2)Fan} heterozygous myoblasts

• however, myoblasts from tamoxifen-treated adults exhibit normal expansive and myogenic potentials

abnormal muscle regeneration ( J:150962 )

• following tamoxifen treatment between P7 and P11, regeneration is severely compromised compared to in control Pax7^{tm2.1(cre/ERT2)Fan} heterozygotes

• however, following tamoxifen treatment between P14 to P18 and P21 to P25 regeneration capacity gradually increased to levels in control Pax7^{tm2.1(cre/ERT2)Fan} heterozygotes

• following tamoxifen treatment, myofibers continue to be incorporated into a regenerating muscle beyond P31 longer than in control Pax7^{tm2.1(cre/ERT2)Fan} heterozygotes

Allelic Composition	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Kdm6a^tm1.1Kaig/Y Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (1006 available)
Kdm6a^tm1.1Kaig mutation (1 available); any Kdm6a mutation (40 available)
Pax7^{tm2.1(cre/ERT2)Fan} mutation (1 available); any Pax7 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

impaired skeletal muscle regeneration ( J:232700 )

• in tamoxifen-treated mice following CTX-induced muscle injury

Allelic Composition	Kdm6a^tm1.1Kaig/Kdm6a^tm1.1Kaig Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm6a^tm1.1Kaig mutation (1 available); any Kdm6a mutation (40 available)
Pax7^{tm2.1(cre/ERT2)Fan} mutation (1 available); any Pax7 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle precursor cell morphology ( J:232700 )

• muscle progenitor cells fail to differentiate ex vitro

impaired skeletal muscle regeneration ( J:232700 )

• following CTX-induced muscle injury, tamoxifen-treated mice exhibit decreased myofiber density with increased necrotic tissues and inflammatory cell infiltration compared with control mice

• however, mice exhibit regeneration of smaller caliber myofibers

Allelic Composition	Kdm6a^tm1.1Kaig/Y Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle precursor cell morphology ( J:232700 )

• muscle progenitor cells fail to differentiate ex vitro

impaired skeletal muscle regeneration ( J:232700 )

• following CTX-induced muscle injury, tamoxifen-treated mice exhibit decreased myofiber density with increased necrotic tissues and inflammatory cell infiltration compared with control mice

• however, mice exhibit regeneration of smaller caliber myofibers

Allelic Composition	Ar^tm2Ska/Ar^tm2Ska Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ar^tm2Ska mutation (0 available); any Ar mutation (23 available)
Pax7^{tm2.1(cre/ERT2)Fan} mutation (1 available); any Pax7 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

muscle phenotype ( J:316008 )

N	• 9-week-old tamoxifen-treated females implanted with a biodegradable pellet containing 10 mg dihydrotestostorone (DHT) to induce muscle hypertrophy show a similar increase in tibialis anterior, quadriceps, and gastrocnemius muscle mass as wild-type mice

Allelic Composition	Kras^tm4Tyj/Kras⁺ Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺ Trp53^tm1Brn/Trp53^tm1Brn
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (12 available); any Kras mutation (87 available)
Pax7^{tm2.1(cre/ERT2)Fan} mutation (1 available); any Pax7 mutation (38 available)
Trp53^tm1Brn mutation (21 available); any Trp53 mutation (243 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:205518 )

• when mice older than 6 weeks are given systemic tamoxifen treatment by intraperitoneal delivery, mice develop multiple tumors (avg. 3.9 per mouse) with 100% penetrance within 1-2 months; median tumor-free survival is 44 days

• tumors develop at various locations, including clinically relevant sites including the orbit

increased sarcoma incidence ( J:205518 )

• tamoxifen treated mice develop tumors displaying a histological spectrum ranging from undifferentiated pleomorphic sarcoma (UPS) to rhabdomyosarcoma (RMS)

• tumors mimic embryonic RMS, pleomorphic RMS, or myogenic or nonmyogenic UPS

• sarcomas can appear in the body wall (37%), the extremities (31%), head and neck (23%), with some being subcutaneous (9%)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24